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Betaxolol
Chemical compound / From Wikipedia, the free encyclopedia
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Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina.[1] It is also a adrenergic blocker with no partial agonist action and minimal membrane stabilizing activity.[2] Being selective for beta1 receptors, it typically has fewer systemic side effects than non-selective beta-blockers, for example, not causing bronchospasm (mediated by beta2 receptors) as timolol may. Betaxolol also shows greater affinity for beta1 receptors than metoprolol. In addition to its effect on the heart, betaxolol reduces the pressure within the eye (intraocular pressure). This effect is thought to be caused by reducing the production of the liquid (which is called the aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma.
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Clinical data | |
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Trade names | Kerlone |
AHFS/Drugs.com | Monograph |
MedlinePlus | a609023 |
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Routes of administration | By mouth, ocular |
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Bioavailability | 89% |
Metabolism | Liver |
Elimination half-life | 14–22 hours |
Excretion | Kidney (20%) |
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ECHA InfoCard | 100.113.058 ![]() |
Chemical and physical data | |
Formula | C18H29NO3 |
Molar mass | 307.434 g·mol−1 |
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Chirality | Racemic mixture |
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It was patented in 1975 and approved for medical use in 1983.[3]