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Cytoplasmic granules in basophils From Wikipedia, the free encyclopedia
Basophilic stippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes in a peripheral blood smear. They can be demonstrated to be RNA. They are composed of aggregates of ribosomes; degenerating mitochondria and siderosomes may be included in the aggregates.[citation needed] In contrast to Pappenheimer bodies, they are negative with Perls' acid ferrocyanide stain for iron (i.e. no iron in basophilic stippling).[1] Basophilic stippling is indicative of disturbed erythropoiesis. It can also be found in some normal individuals.[2]
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