Anti-neurofascin demyelinating diseases
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Anti-neurofascin demyelinating diseases (anti-NF diseases) refers to health conditions engendered by auto-antibodies against neurofascins, which can produce both central and peripheral demyelination. Some cases of combined central and peripheral demyelination (CCPD) could be produced by them.[1][non-primary source needed]
- Chronic inflammatory demyelinating polyneuropathy: Some cases of CIDP are reported to be produced by auto-antibodies against several neurofascin proteins. These proteins are present in the neurons and four of them have been reported to produce disease: NF186, NF180, NF166 and NF155.[2]
- Neuromyelitis optica: NF auto antibodies can also appear in NMO cases.[2] These antibodies are more related to the peripheral nervous demyelination, but they were also found in NMO.[3][non-primary source needed]
- Multiple sclerosis: Also antibodies against Neurofascins NF-155 can also appear in atypical multiple sclerosis[4] and NF-186 could be involved in subtypes of MS[5] yielding an intersection between both conditions. Around 10% of MS cases are now thought to be anti-NF cases.[6][7]
This article needs more reliable medical references for verification or relies too heavily on primary sources, specifically: It relies too much on primary sources. (June 2022) |