Adaptive response
Cellular activity in E. coli / From Wikipedia, the free encyclopedia
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The adaptive response is a DNA damage response pathway prevalent across bacteria that protects DNA from damage by external agents or by errors during replication.[1][2] It is initiated specifically against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA. Under sustained exposure to low-level treatment with alkylating mutagens, bacteria can adapt to the presence of the mutagen, rendering subsequent treatment with high doses of the same agent less effective.[3][4]