![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/1/17/Acepromazine.svg/640px-Acepromazine.svg.png&w=640&q=50)
Acepromazine
Antipsychotic medication / From Wikipedia, the free encyclopedia
Acepromazine, acetopromazine, or acetylpromazine (commonly known as ACP, Ace, or by the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during the 1950s as an antipsychotic,[4] but is now almost exclusively used on animals as a sedative and antiemetic. A closely related analogue, chlorpromazine, is still used in humans.
![]() | |
Clinical data | |
---|---|
Trade names | Atravet, Acezine 2 |
AHFS/Drugs.com | International Drug Names |
Routes of administration | IV, IM, SQ, oral[1][2] |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 6.6 L/kg, high volume of distribution |
Elimination half-life | 3 hours in horses, 15.9 hours in canines |
Excretion | urine |
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.451 ![]() |
Chemical and physical data | |
Formula | C19H22N2OS |
Molar mass | 326.46 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
The standard pharmaceutical preparation, acepromazine maleate, is used in veterinary medicine in dogs and cats. It is used widely in horses as a pre-anesthetic sedative and has been shown to reduce anesthesia related death.[5] However, it should be used with caution (but is not absolutely contraindicated) in stallions due to the risk of paraphimosis and priapism.[6] Its potential for cardiac effects can be profound, namely hypotension due to peripheral vasodilation, so it should be avoided or used with caution in geriatric or debilitated animals.[7]