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AXL receptor tyrosine kinase
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene.[5][6] The gene was initially designated as UFO, in allusion to the unidentified function of this protein.[7] However, in the years since its discovery, research into AXL's expression profile and mechanism has made it an increasingly attractive target, especially for cancer therapeutics. In recent years, AXL has emerged as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers.[8]
AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK.[9]