ATP8B3

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.^[5]

ATP8B3
Identifiers
Aliases	ATP8B3, ATPIK, ATPase phospholipid transporting 8B3
External IDs	OMIM: 605866; MGI: 1914581; HomoloGene: 19034; GeneCards: ATP8B3; OMA:ATP8B3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,782,075 bp[1] End 1,812,276 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,355,418 bp[2] End 80,374,958 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis buccal mucosa cell stromal cell of endometrium right adrenal gland right adrenal cortex granulocyte testicle left adrenal gland left adrenal cortex Top expressed in spermatid spermatocyte seminiferous tubule olfactory epithelium embryo facial motor nucleus epiblast islet of Langerhans tail of embryo anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding metal ion binding ATPase-coupled intramembrane lipid transporter activity hydrolase activity ATP binding magnesium ion binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane plasma membrane acrosomal membrane endoplasmic reticulum cytoplasmic vesicle acrosomal vesicle Biological process lipid transport Golgi organization phospholipid transport phospholipid translocation binding of sperm to zona pellucida Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 148229 67331 Ensembl ENSG00000130270 ENSMUSG00000003341 UniProt O60423 Q6UQ17 RefSeq (mRNA) NM_001178002 NM_138813 NM_026094 RefSeq (protein) NP_001171473 NP_620168 NP_080370 Location (UCSC) Chr 19: 1.78 – 1.81 Mb Chr 10: 80.36 – 80.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcript

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5]

Protein

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

References

1. GRCh38: Ensembl release 89: ENSG00000130270 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003341 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ATPase, aminophospholipid transporter, class I, type 8B, member 3". Retrieved 2011-10-22.

External links

• Human ATP8B3 genome location and ATP8B3 gene details page in the UCSC Genome Browser.

Further reading

• Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (November 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. doi:10.1152/physiolgenomics.1999.1.3.139. PMID 11015572. S2CID 762447.
• Harris MJ, Arias IM (July 2003). "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1633 (2): 127–31. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872.
• Fries AS, Svendsen O (January 1978). "Studies on Tyzzer's disease in rats". Laboratory Animals. 12 (1): 1–4. doi:10.1258/002367778780953297. PMID 146761. S2CID 8184958.
• Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M (May 2009). "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 106 (18): 7501–6. Bibcode:2009PNAS..106.7501S. doi:10.1073/pnas.0813386106. PMC 2678639. PMID 19416921.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.