ATP11B

Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.^[5][6][7]

ATP11B
Identifiers
Aliases	ATP11B, ATPIF, ATPIR, ATPase phospholipid transporting 11B (putative)
External IDs	OMIM: 605869; MGI: 1923545; HomoloGene: 32919; GeneCards: ATP11B; OMA:ATP11B - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 182,793,503 bp[1] End 182,921,629 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 35,808,255 bp[2] End 35,910,425 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon bone marrow cells sperm gingival epithelium secondary oocyte Skeletal muscle tissue of rectus abdominis oral cavity tonsil germinal epithelium Top expressed in neural layer of retina granulocyte cumulus cell large intestine colon left colon epithelium of small intestine pyloric antrum blood jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ion transmembrane transporter activity metal ion binding protein binding ATPase-coupled intramembrane lipid transporter activity hydrolase activity ATP binding magnesium ion binding Cellular component integral component of membrane recycling endosome endosome Golgi apparatus membrane plasma membrane nuclear inner membrane recycling endosome membrane early endosome endoplasmic reticulum azurophil granule membrane trans-Golgi network Biological process lipid transport aminophospholipid transport phospholipid transport ion transport ion transmembrane transport phospholipid translocation neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23200 76295 Ensembl ENSG00000058063 ENSMUSG00000037400 UniProt Q9Y2G3 Q6DFW5 RefSeq (mRNA) NM_014616 NM_029570 RefSeq (protein) NP_055431 NP_083846 Location (UCSC) Chr 3: 182.79 – 182.92 Mb Chr 3: 35.81 – 35.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000058063 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037400 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
6. Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (Nov 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. doi:10.1152/physiolgenomics.1999.1.3.139. PMID 11015572. S2CID 762447.
7. "Entrez Gene: ATP11B ATPase, Class VI, type 11B".

External links

• Human ATP11B genome location and ATP11B gene details page in the UCSC Genome Browser.

Further reading

• Halleck MS, Schlegel RA, Williamson PL (Mar 2002). "Reanalysis of ATP11B, a type IV P-type ATPase". The Journal of Biological Chemistry. 277 (12): 9736–40. doi:10.1074/jbc.M200240200. PMID 11790799.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.