ARF6

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

ARF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E0S, 2A5D, 2A5F, 2A5G, 2BAO, 2BAU, 2J5X, 2W83, 3LVQ, 3LVR, 4FME, 3N5C, 3PCR, 4KAX
Identifiers
Aliases	ARF6, ADP-ribosylation factor 6, ADP ribosylation factor 6
External IDs	OMIM: 600464; MGI: 99435; HomoloGene: 1256; GeneCards: ARF6; OMA:ARF6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.3 Start 49,893,079 bp[1] End 49,897,054 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,418,924 bp[2] End 69,420,557 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium oral cavity amniotic fluid buccal mucosa cell human penis vulva germinal epithelium trabecular bone mucosa of sigmoid colon parietal pleura Top expressed in conjunctival fornix cumulus cell hair follicle Paneth cell condyle endocardial cushion endothelial cell of lymphatic vessel seminal vesicula semi-lunar valve motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein N-terminus binding GTP binding protein binding GTPase activity thioesterase binding Cellular component cytoplasm recycling endosome endosome Golgi apparatus cell projection membrane focal adhesion ruffle myelin sheath plasma membrane endocytic vesicle intracellular anatomical structure cell cortex early endosome endosome membrane extracellular exosome filopodium membrane recycling endosome membrane cleavage furrow cytosol Flemming body early endosome membrane presynapse glutamatergic synapse Biological process establishment of epithelial cell polarity cell differentiation regulation of filopodium assembly positive regulation of actin filament polymerization ruffle organization small GTPase mediated signal transduction regulation of Rac protein signal transduction nervous system development negative regulation of dendrite development cell division negative regulation of receptor-mediated endocytosis cell adhesion protein localization to cell surface protein transport protein localization to endosome cell cycle liver development myeloid cell apoptotic process cortical actin cytoskeleton organization vesicle-mediated transport regulation of dendritic spine development hepatocyte apoptotic process transport positive regulation of protein localization to plasma membrane intracellular protein transport regulation of neuron projection development endocytic recycling synaptic vesicle endocytosis positive regulation of keratinocyte migration ruffle assembly maintenance of postsynaptic density structure positive regulation of adherens junction organization regulation of presynapse assembly cellular response to nerve growth factor stimulus negative regulation of protein localization to cell surface positive regulation of protein secretion positive regulation of protein homodimerization activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 382 11845 Ensembl ENSG00000165527 ENSMUSG00000044147 UniProt P62330 P62331 RefSeq (mRNA) NM_001663 NM_007481 RefSeq (protein) NP_001654 NP_031507 Location (UCSC) Chr 14: 49.89 – 49.9 Mb Chr 12: 69.42 – 69.42 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.^[5]

ARF6 can interact with βarrestin upon receptor activation.

Interactions

ARF6 has been shown to interact with:

• ARRB1^[6]
• ARFIP2^[7][8]
• CHRM3^[9]
• EXOC5^[10]
• KIAA0090^[11]
• Rac1^[12]