ALDH1L2

Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene.^[5][6] ALDH1L2 is the mitochondrial isoform of a similar enzyme, ALDH1L1, which converts 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.^[7][8]

ALDH1L2
Identifiers
Aliases	ALDH1L2, mtFDH, aldehyde dehydrogenase 1 family member L2
External IDs	OMIM: 613584; MGI: 2444680; HomoloGene: 51942; GeneCards: ALDH1L2; OMA:ALDH1L2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.3 Start 105,019,784 bp[1] End 105,107,643 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 83,323,314 bp[2] End 83,370,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia body of pancreas stromal cell of endometrium pancreatic epithelial cell parotid gland Achilles tendon tendon of biceps brachii islet of Langerhans bone marrow cells Descending thoracic aorta Top expressed in parotid gland calvaria lacrimal gland body of femur fossa submandibular gland atrium umbilical cord pancreas islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function hydroxymethyl-, formyl- and related transferase activity formyltetrahydrofolate dehydrogenase activity oxidoreductase activity catalytic activity aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Cellular component extracellular exosome cytoplasm mitochondrion mitochondrial matrix nucleus Biological process one-carbon metabolic process biosynthesis 10-formyltetrahydrofolate catabolic process metabolism folic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 160428 216188 Ensembl ENSG00000136010 ENSMUSG00000020256 UniProt Q3SY69 Q8K009 RefSeq (mRNA) NM_001034173 NM_153543 RefSeq (protein) NP_001029345 NP_705771 Location (UCSC) Chr 12: 105.02 – 105.11 Mb Chr 10: 83.32 – 83.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136010 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020256 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. Ota T, Suzuki Y, Nishikawa T, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
7. Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. "ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase." J Biol Chem. 2010 Jul 23;285(30):23056-63.
8. Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA. "Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahdyrofolate dehydrogenase." Chem Biol Interact. 2011 May 30;191(1-3):129-36.

External links

• Human ALDH1L2 genome location and ALDH1L2 gene details page in the UCSC Genome Browser.

Further reading

• Strickland KC, Hoeferlin LA, Oleinik NV, et al. (2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275.