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7-Nitroindazole
Chemical compound / From Wikipedia, the free encyclopedia
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7-Nitroindazole, or 7-NI, is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. Nitroindazole acts as a selective inhibitor for neuronal nitric oxide synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).[1] Nitric oxide can diffuse through the plasma membrane into neighbouring cells, allowing cell signalling, so nitroindazole indirectly inhibits this signalling process.[2][3][4] Other inhibitors exist such as 3-bromo-7-nitroindazole, which is more potent but less specific,[5] or NPA (N-propyl-L-arginine), which acts on a different site.[6]
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Names | |
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Preferred IUPAC name
7-Nitro-1H-indazole | |
Identifiers | |
3D model (JSmol) |
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ChEMBL | |
ChemSpider |
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ECHA InfoCard | 100.019.032 ![]() |
PubChem CID |
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CompTox Dashboard (EPA) |
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Properties | |
C7H5N3O2 | |
Molar mass | 163.1335 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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