Events from the year 1754 in Great Britain.
- 6 February – Andrew Fuller, Particular Baptist minister, promoter of missionary work (died 1815)
- 16 June – Peter Burrell, 1st Baron Gwydyr, English politician and co-founder of the Marylebone Cricket Club (died 1820)
- 11 July – Thomas Bowdler, physician (died 1825)
- 21 August – William Murdoch, inventor (died 1839)
- 7 September – Elizabeth Ann Linley, singer, wife of Richard Brinsley Sheridan (died 1792)
- 9 September – William Bligh, sailor (died 1817)
- 24 December – George Crabbe, poet (died 1832)
- 10 January – Edward Cave, editor and publisher (born 1691)
- 16 February – Richard Mead, physician (born 1673)
- 27 February – John Brownlow, 1st Viscount Tyrconnel, English politician (born 1690)
- 6 March – Henry Pelham, Prime Minister (born 1696)
- 2 April – Thomas Carte, historian (born 1686)
- 23 May – John Wood, the Elder, architect (born 1704)
- 2 June – Ebenezer Erskine, Scottish Secessionist minister (born 1680)
- 7 July – Frances Seymour, Duchess of Somerset (born 1699)
- 23 August – William Cleghorn, Scottish philosopher (born 1718)
- 29 September – William Keen, first resident judicial officer in the British colony of Newfoundland (born c. 1680)
- 8 October – Henry Fielding, novelist (born 1707)
Palmer, Alan; Palmer, Veronica (1992). The Chronology of British History. London: Century Ltd. pp. 220–221. ISBN 0-7126-5616-2.