Events from the year 1681 in England.
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- January – William Walwyn, Leveller (born c. 1600)
- 28 January – Richard Allestree, royalist churchman (born c. 1621)
- c. 30 January – John Watling, buccaneer (year of birth unknown)
- 5 March – Sir Jonathan Trelawny, 2nd Baronet, Member of Parliament (born c. 1623)
- 14 April – Sir Thomas Littleton, 2nd Baronet, Member of Parliament (born c. 1621)
- 18 April – John Loosemore, pipe organ builder (born 1616)
- 9 June – William Lilly, astrologer and occultist (born 1602)
- 26 July – Sir Thomas Isham, 3rd Baronet, aristocrat and diarist (born 1657)
- 14 September (bur.) – Hezekiah Burton, theologian (born 1632)
- 15 December – James Compton, 3rd Earl of Northampton, soldier and politician (born 1622)
- 22 December – Richard Alleine, Puritan clergyman (born 1611)
- Elizabeth Knepp, actress (year of birth unknown)
Palmer, Alan; Palmer, Veronica (1992). The Chronology of British History. London: Century Ltd. pp. 194–196. ISBN 0-7126-5616-2.