TRPV1

TRPV1
Dynodwyr
Cyfenwau	TRPV1, VR1, transient receptor potential cation channel subfamily V member 1
Dynodwyr allanol	OMIM: 602076 HomoloGene: 12920 GeneCards: TRPV1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • ion channel activity; • phosphoprotein binding; • ATP binding; • cation transmembrane transporter activity; • cation channel activity; • ligand-gated ion channel activity; • calcium-release channel activity; • temperature-gated ion channel activity; • identical protein binding; • chloride channel regulator activity; • transmembrane signaling receptor activity; • excitatory extracellular ligand-gated ion channel activity; • calcium channel activity; • extracellular ligand-gated ion channel activity; • phosphatidylinositol binding; • metal ion binding; • calmodulin binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• integral component of membrane; • postsynaptic membrane; • cell projection; • bilen; • Cellbilen; • synapse; • cell junction; • dendritic spine membrane; • cytosol; • soma; • intrinsic component of plasma membrane; • dendrite; • external side of plasma membrane; • neuron projection; • integral component of plasma membrane; • mitocondria;
Prosesau biolegol	• cludo ïon; • chemosensory behavior; • cell surface receptor signaling pathway; • calcium ion transmembrane transport; • thermoception; • calcium ion transport; • inflammatory response; • transmembrane transport; • release of sequestered calcium ion into cytosol; • GO:1901227 negative regulation of transcription by RNA polymerase II; • diet induced thermogenesis; • detection of chemical stimulus involved in sensory perception of pain; • microglial cell activation; • cellular response to growth factor stimulus; • positive regulation of gastric acid secretion; • response to peptide hormone; • cellular response to nerve growth factor stimulus; • positive regulation of nitric oxide biosynthetic process; • negative regulation of establishment of blood-brain barrier; • lipid metabolism; • temperature homeostasis; • response to heat; • cellular response to temperature stimulus; • positive regulation of cytosolic calcium ion concentration; • peptide secretion; • detection of temperature stimulus involved in sensory perception of pain; • sensory perception of mechanical stimulus; • smooth muscle contraction involved in micturition; • behavioral response to pain; • response to pain; • cellular response to alkaloid; • cellular response to cytokine stimulus; • fever generation; • detection of temperature stimulus involved in thermoception; • positive regulation of apoptotic process; • urinary bladder smooth muscle contraction; • glutamate secretion; • sensory perception of pain; • cellular response to tumor necrosis factor; • cellular response to ATP; • cludo transmembrane rhwng ïonau; • response to pH; • response to organonitrogen compound; • cellular response to heat; • protein homotetramerization; • excitatory postsynaptic potential; • cellular response to acidic pH; • response to capsazepine; • calcium ion import across plasma membrane; • negative regulation of systemic arterial blood pressure; • negative regulation of heart rate; • negative regulation of mitochondrial membrane potential;
	Sources:Amigo / QuickGO
Orthologau
	7442
	n/a
	ENSG00000196689
	n/a
	Q8NER1
	n/a
	NM_018727; NM_080704; NM_080705; NM_080706
	n/a
	NP_061197; NP_542435; NP_542436; NP_542437
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRPV1 yw TRPV1 a elwir hefyd yn Transient receptor potential cation channel subfamily V member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.2.^[2]

Ffeithiau sydyn Dynodwyr, Cyfenwau ...

Cau

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRPV1.

VR1

"Immediate and delayed potentiating effects of tumor necrosis factor-α on TRPV1 sensitivity of rat vagal pulmonary sensory neurons. ". Am J Physiol Lung Cell Mol Physiol. 2017. PMID 28522561.
"Role of transient receptor potential vanilloid 1 in the modulation of airway smooth muscle tone and calcium handling. ". Am J Physiol Lung Cell Mol Physiol. 2017. PMID 28336810.
"TRPV1 polymorphisms and risk of interferon β-induced flu-like syndrome in patients with relapsing-remitting multiple sclerosis. ". J Neuroimmunol. 2017. PMID 28284340.
"Protein toxins of the Echis coloratus viper venom directly activate TRPV1. ". Biochim Biophys Acta. 2017. PMID 28063984.
"Understand spiciness: mechanism of TRPV1 channel activation by capsaicin.". Protein Cell. 2017. PMID 28044278.

[1] [1]
"Human PubMed Reference:".

[2] [2]
TRPV1 - Cronfa NCBI

[2]

[1]

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