MAPK10

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK10 yw MAPK10 a elwir hefyd yn Mitogen-activated protein kinase 10 a MAPK10 protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q21.3.^[2]

MAPK10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JNK, 1PMN, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B, 4KKG, 4KKH, 4U79, 4W4V, 4W4W, 4W4X, 4W4Y, 4WHZ, 4Y46, 4Y5H, 4Z9L, 4X21
Dynodwyr
Cyfenwau	MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10
Dynodwyr allanol	OMIM: 602897 HomoloGene: 56439 GeneCards: MAPK10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • MAP kinase kinase activity • JUN kinase activity Cydrannau o'r gell • cytosol • bilen • mitocondria • Cellbilen • cnewyllyn cell • cytoplasm • neuron projection • nucleoplasm • perikaryon • glutamatergic synapse • intracellular anatomical structure Prosesau biolegol • phosphorylation • response to light stimulus • proses rythmig • Fc-epsilon receptor signaling pathway • protein phosphorylation • regulation of circadian rhythm • GO:0072468 signal transduction • JUN phosphorylation • JNK cascade • regulation of gene expression • neuron development • GO:0007243 intracellular signal transduction • cellular response to organic substance • GO:1901227 negative regulation of transcription by RNA polymerase II • response to water deprivation • cellular hyperosmotic response • neurotransmitter receptor transport to postsynaptic membrane • vesicle-mediated transport in synapse • regulation of DNA-binding transcription factor activity • MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5602	n/a
Ensembl	ENSG00000109339	n/a
UniProt	P53779 Q499Y8	n/a
RefSeq (mRNA)	NM_002753 NM_138980 NM_138981 NM_138982 NM_001318067 NM_001318068 NM_001318069 NM_001351624 NM_001351625 NM_001363657	n/a
RefSeq (protein)	NP_001304996 NP_001304997 NP_001304998 NP_002744 NP_620446 NP_620448 NP_001338553 NP_001338554 NP_001350586 NP_001304997.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK10.

• JNK3
• JNK3A
• PRKM10
• SAPK1b
• p493F12
• p54bSAPK

Llyfryddiaeth

• "Phosphorylation- and nucleotide-binding-induced changes to the stability and hydrogen exchange patterns of JNK1β1 provide insight into its mechanisms of activation. ". J Mol Biol. 2014. PMID 25178256.
• "JNK3 is required for the cytoprotective effect of exendin 4. ". J Diabetes Res. 2014. PMID 25025079.
• "Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10. ". Oncol Rep. 2017. PMID 28393229.
• "Peptide mini-scaffold facilitates JNK3 activation in cells. ". Sci Rep. 2016. PMID 26868142.
• "Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline.". J Psychiatry Neurosci. 2015. PMID 25455349.

Cyfeiriadau

1. "Human PubMed Reference:".
2. MAPK10 - Cronfa NCBI