FGF2

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF2 yw FGF2 a elwir hefyd yn Fibroblast growth factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q28.1.^[2]

FGF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG
Dynodwyr
Cyfenwau	FGF2, BFGF, FGF-2, FGFB, HBGF-2, fibroblast growth factor 2
Dynodwyr allanol	OMIM: 134920 HomoloGene: 1521 GeneCards: FGF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • heparin binding • fibroblast growth factor receptor binding • GO:0001948, GO:0016582 protein binding • nuclear receptor coactivator activity • chemoattractant activity • growth factor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • receptor-receptor interaction • integrin binding Cydrannau o'r gell • extracellular region • cnewyllyn cell • extracellular space Prosesau biolegol • release of sequestered calcium ion into cytosol • cell differentiation • negative regulation of fibroblast migration • hyaluronan catabolic process • positive regulation of endothelial cell proliferation • positive regulation of MAP kinase activity • negative regulation of blood vessel endothelial cell migration • positive regulation of endothelial cell chemotaxis to fibroblast growth factor • somatic stem cell population maintenance • positive regulation of phospholipase C activity • extracellular matrix organization • wound healing • negative regulation of cell death • regulation of angiogenesis • nervous system development • cell migration involved in sprouting angiogenesis • MAPK cascade • positive regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase activity • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • chemotaxis • fibroblast growth factor receptor signaling pathway • chondroblast differentiation • multicellular organism development • growth factor dependent regulation of skeletal muscle satellite cell proliferation • branching involved in ureteric bud morphogenesis • positive regulation of cardiac muscle cell proliferation • embryonic morphogenesis • angiogenesis • positive regulation of cell fate specification • animal organ morphogenesis • regulation of endothelial cell chemotaxis to fibroblast growth factor • phosphatidylinositol biosynthetic process • inositol phosphate biosynthetic process • negative regulation of wound healing • Ras protein signal transduction • positive regulation of cell division • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive chemotaxis • phosphatidylinositol phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • positive regulation of cell population proliferation • phosphatidylinositol-3-phosphate biosynthetic process • stem cell proliferation • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • cytokine-mediated signaling pathway • positive regulation of blood vessel endothelial cell migration • positive regulation of ERK1 and ERK2 cascade • positive regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular endothelial cell proliferation • positive regulation of cell migration involved in sprouting angiogenesis • paracrine signaling • positive regulation of DNA biosynthetic process • positive regulation of endothelial cell chemotaxis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2247	n/a
Ensembl	ENSG00000138685	n/a
UniProt	P09038	n/a
RefSeq (mRNA)	NM_002006 NM_001361665	n/a
RefSeq (protein)	NP_001997 NP_001348594	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF2.

• BFGF
• FGFB
• FGF-2
• HBGF-2

Llyfryddiaeth

• "bFGFPolymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients. ". Anticancer Res. 2017. PMID 28373444.
• "Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration. ". Exp Cell Res. 2017. PMID 28363830.
• "Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell-Airway Smooth Muscle Cell Communication through Membrane Conduits. ". J Immunol. 2017. PMID 28924004.
• "siRNA-mediated silencing of bFGF gene inhibits the proliferation, migration, and invasion of human pituitary adenoma cells. ". Tumour Biol. 2017. PMID 28656882.
• "Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer.". Oncotarget. 2017. PMID 28423625.

Cyfeiriadau

1. "Human PubMed Reference:".
2. FGF2 - Cronfa NCBI