Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP2D6 yw CYP2D6 a elwir hefyd yn Cytochrome P450 family 2 subfamily D member 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.2.[2]
Ffeithiau sydyn Strwythurau, PDB ...
CYP2D6 |
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Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Dynodwyr |
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Cyfenwau | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6 |
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Dynodwyr allanol | OMIM: 124030 HomoloGene: 133550 GeneCards: CYP2D6 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • iron ion binding • metal ion binding • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • steroid hydroxylase activity • monooxygenase activity
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Cydrannau o'r gell | • organelle membrane • endoplasmic reticulum membrane • bilen • intracellular membrane-bounded organelle • Reticwlwm endoplasmig • mitocondria • cytoplasm
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Prosesau biolegol | • steroid metabolic process • alkaloid metabolic process • coumarin metabolic process • lipid metabolism • isoquinoline alkaloid metabolic process • GO:1900774, GO:1900783, GO:1900795, GO:1901084, GO:1900780, GO:1900777, GO:1900771, GO:1901014, GO:1902180, GO:1900987, GO:1900990 alkaloid catabolic process • oxidative demethylation • heterocycle metabolic process • negative regulation of binding • monoterpenoid metabolic process • xenobiotic metabolic process • arachidonic acid metabolic process • negative regulation of cellular organofluorine metabolic process • long-chain fatty acid biosynthetic process • organic acid metabolic process
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Cau
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP2D6.
- CPD6
- CYP2D
- CYP2DL1
- CYPIID6
- P450C2D
- P450DB1
- CYP2D7AP
- CYP2D7BP
- CYP2D7P2
- CYP2D8P2
- P450-DB1
- "Inference of the Genetic Polymorphisms of CYP2D6 in Six Subtribes of the Malaysian Orang Asli from Whole-Genome Sequencing Data. ". Genet Test Mol Biomarkers. 2017. PMID 28525288.
- "Effect of 22 CYP2D6 variants found in the Chinese population on tolterodine metabolism in vitro. ". Chem Biol Interact. 2017. PMID 28087463.
- "Significant Effect of Polymorphisms in CYP2D6on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study. ". Clin Cancer Res. 2017. PMID 27797974.
- "Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis. ". Immunol Invest. 2017. PMID 27749127.
- "Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis.". Acta Pharmacol Sin. 2016. PMID 27665849.