TRADD

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRADD yw TRADD a elwir hefyd yn TNFRSF1A associated via death domain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q22.1.^[2]

TRADD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1F2H, 1F3V
Dynodwyr
Cyfenwau	TRADD, Hs.89862, TNFRSF1A associated via death domain
Dynodwyr allanol	OMIM: 603500 HomoloGene: 2807 GeneCards: TRADD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • death domain binding • kinase binding • GO:0001948, GO:0016582 protein binding • identical protein binding • tumor necrosis factor receptor binding • GO:0032403 protein-containing complex binding • GO:0032947 molecular adaptor activity • transmembrane receptor protein tyrosine kinase adaptor activity Cydrannau o'r gell • cytoplasm • cytosol • receptor complex • Cellbilen • death-inducing signaling complex • membrane raft • Cytosgerbwd • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • extrinsic apoptotic signaling pathway • positive regulation of hair follicle development • regulation of tumor necrosis factor-mediated signaling pathway • tumor necrosis factor-mediated signaling pathway • death-inducing signaling complex assembly • positive regulation of NF-kappaB transcription factor activity • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of extrinsic apoptotic signaling pathway via death domain receptors • I-kappaB kinase/NF-kappaB signaling • activation of cysteine-type endopeptidase activity involved in apoptotic process • extrinsic apoptotic signaling pathway via death domain receptors • GO:0072468 signal transduction • GO:0097285 apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • protein heterooligomerization • positive regulation of cell migration • positive regulation of inflammatory response • cellular response to tumor necrosis factor • positive regulation of NIK/NF-kappaB signaling • transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8717	n/a
Ensembl	ENSG00000102871	n/a
UniProt	Q15628	n/a
RefSeq (mRNA)	NM_003789 NM_153425 NM_001323552	n/a
RefSeq (protein)	NP_001310481 NP_003780	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRADD.

• Hs.89862

Llyfryddiaeth

• "Anticancer activity of an antisense oligonucleotide targeting TRADD combined with proteasome inhibitors in chemoresistant hepatocellular carcinoma cells. ". J Chemother. 2013. PMID 24070137.
• "The role of TRADD in death receptor signaling. ". Cell Cycle. 2012. PMID 22333735.
• "Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS. ". Pediatr Blood Cancer. 2008. PMID 18661484.
• "The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway. ". J Biomol NMR. 2007. PMID 17922260.
• "Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein.". Clin Cancer Res. 2003. PMID 12576460.

Cyfeiriadau

1. "Human PubMed Reference:".
2. TRADD - Cronfa NCBI