TGFB1

TGFB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Dynodwyr
Cyfenwau	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta 1, IBDIMDE, TGF-beta1
Dynodwyr allanol	OMIM: 190180 HomoloGene: 540 GeneCards: TGFB1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• type II transforming growth factor beta receptor binding; • protein N-terminus binding; • cytokine activity; • enzyme binding; • growth factor activity; • GO:0003823, GO:0051635 antigen binding; • type I transforming growth factor beta receptor binding; • protein homodimerization activity; • protein serine/threonine kinase activator activity; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity; • type III transforming growth factor beta receptor binding; • transforming growth factor beta receptor binding; • identical protein binding;
Cydrannau o'r gell	• cytoplasm; • extracellular region; • cnewyllyn cell; • microvillus; • cell surface; • blood microparticle; • Cellbilen; • secretory granule; • axon; • soma; • Golgi lumen; • platelet alpha granule lumen; • GO:0005578 extracellular matrix; • extracellular space;
Prosesau biolegol	• positive regulation of histone deacetylation; • positive regulation of transcription regulatory region DNA binding; • ureteric bud development; • tolerance induction to self antigen; • positive regulation of protein phosphorylation; • endoderm development; • response to cholesterol; • positive regulation of MAP kinase activity; • regulation of sodium ion transport; • response to progesterone; • negative regulation of cell cycle; • response to organic substance; • mammary gland development; • T cell homeostasis; • negative regulation of ossification; • negative regulation of hyaluronan biosynthetic process; • protein phosphorylation; • T cell differentiation; • positive regulation of vascular permeability; • animal organ regeneration; • positive regulation of blood vessel endothelial cell migration; • negative regulation of epithelial cell proliferation; • regulation of binding; • inner ear development; • myelination; • negative regulation of macrophage cytokine production; • cell population proliferation; • transforming growth factor beta receptor signaling pathway; • face morphogenesis; • negative regulation of cell population proliferation; • positive regulation of receptor clustering; • regulation of apoptotic process; • positive regulation of collagen biosynthetic process; • cellular response to transforming growth factor beta stimulus; • pathway-restricted SMAD protein phosphorylation; • regulation of DNA binding; • regulation of actin cytoskeleton reorganization; • negative regulation of fat cell differentiation; • GO:0051247, GO:0051200 positive regulation of protein metabolic process; • cell-cell junction organization; • negative regulation of myoblast differentiation; • positive regulation of protein kinase B signaling; • common-partner SMAD protein phosphorylation; • positive regulation of branching involved in ureteric bud morphogenesis; • SMAD protein signal transduction; • epidermal growth factor receptor signaling pathway; • macrophage derived foam cell differentiation; • negative regulation of blood vessel endothelial cell migration; • positive regulation of protein dephosphorylation; • extrinsic apoptotic signaling pathway; • negative regulation of extracellular matrix disassembly; • mitotic cell cycle checkpoint signaling; • positive regulation of fibroblast proliferation; • negative regulation of cell differentiation; • regulation of branching involved in mammary gland duct morphogenesis; • positive regulation of exit from mitosis; • negative regulation of transforming growth factor beta receptor signaling pathway; • negative regulation of gene expression; • morphogenesis of a branching structure; • regulation of SMAD protein signal transduction; • positive regulation of peptidyl-serine phosphorylation; • cell activation; • negative regulation of neuroblast proliferation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • cell growth; • negative regulation of T cell proliferation; • response to wounding; • negative regulation of cell growth; • positive regulation of chemotaxis; • protein export from nucleus; • regulation of protein import into nucleus; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of protein import into nucleus; • positive regulation of cardiac muscle cell differentiation; • oligodendrocyte development; • positive regulation of interleukin-17 production; • inflammatory response; • negative regulation of interleukin-17 production; • lymph node development; • T cell activation; • Notch signaling pathway; • GO:0033128 negative regulation of protein phosphorylation; • regulation of blood vessel remodeling; • SMAD protein complex assembly; • regulation of striated muscle tissue development; • response to vitamin D; • chondrocyte differentiation; • regulatory T cell differentiation; • regulation of cartilage development; • branch elongation involved in mammary gland duct branching; • positive regulation of bone mineralization; • positive regulation of epithelial cell proliferation; • female pregnancy; • GO:1904579 cellular response to organic cyclic compound; • positive regulation of extracellular matrix assembly; • cellular calcium ion homeostasis; • wound healing; • GO:1901227 negative regulation of transcription by RNA polymerase II; • response to glucose; • positive regulation of epithelial to mesenchymal transition; • cellular response to dexamethasone stimulus; • negative regulation of production of miRNAs involved in gene silencing by miRNA; • GO:0019049, GO:0030683 mitigation of host defenses by virus; • lens fiber cell differentiation; • positive regulation of NF-kappaB transcription factor activity; • extracellular matrix assembly; • ATP biosynthetic process; • hematopoietic progenitor cell differentiation; • regulation of interleukin-23 production; • positive regulation of protein secretion; • frontal suture morphogenesis; • epithelial to mesenchymal transition; • phosphate-containing compound metabolic process; • regulation of gene expression; • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; • negative regulation of release of sequestered calcium ion into cytosol; • response to radiation; • mononuclear cell proliferation; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of T cell activation; • positive regulation of odontogenesis; • lipopolysaccharide-mediated signaling pathway; • positive regulation of protein localization to nucleus; • response to estradiol; • regulation of cell migration; • response to hypoxia; • hyaluronan catabolic process; • negative regulation of phagocytosis; • GO:1904578 response to organic cyclic compound; • positive regulation of protein-containing complex assembly; • protein kinase B signaling; • negative regulation of cell-cell adhesion; • GO:1905617 negative regulation of gene silencing by miRNA; • positive regulation of regulatory T cell differentiation; • cellular response to growth factor stimulus; • positive regulation of pathway-restricted SMAD protein phosphorylation; • mammary gland branching involved in thelarche; • response to laminar fluid shear stress; • GO:0010260 heneiddio; • regulation of regulatory T cell differentiation; • platelet degranulation; • negative regulation of DNA replication; • myeloid dendritic cell differentiation; • salivary gland morphogenesis; • receptor catabolic process; • MAPK cascade; • positive regulation of histone acetylation; • regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of phosphatidylinositol 3-kinase activity; • negative regulation of protein localization to plasma membrane; • positive regulation of NAD+ ADP-ribosyltransferase activity; • negative regulation of immune response; • regulation of cell population proliferation; • negative regulation of skeletal muscle tissue development; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of smooth muscle cell differentiation; • positive regulation of isotype switching to IgA isotypes; • connective tissue replacement involved in inflammatory response wound healing; • ossification involved in bone remodeling; • positive regulation of apoptotic process; • positive regulation of vascular endothelial growth factor production; • positive regulation of superoxide anion generation; • digestive tract development; • cell migration; • positive regulation of fibroblast migration; • positive regulation of cell division; • germ cell migration; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of mitotic cell cycle; • positive regulation of SMAD protein signal transduction; • positive regulation of pri-miRNA transcription by RNA polymerase II; • GO:1901313 positive regulation of gene expression; • positive regulation of cell population proliferation; • liver regeneration; • regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; • positive regulation of mononuclear cell migration; • cellular response to insulin-like growth factor stimulus; • positive regulation of cell migration; • response to immobilization stress; • cellular response to mechanical stimulus; • cellular response to ionizing radiation; • vasculogenesis; • neural tube closure; • heart valve morphogenesis; • heart development; • neural tube development; • membrane protein intracellular domain proteolysis; • leukocyte migration; • ventricular cardiac muscle tissue morphogenesis; • positive regulation of ERK1 and ERK2 cascade; • transforming growth factor beta receptor signaling pathway involved in heart development; • embryonic liver development; • BMP signaling pathway; • cell development; • GO:0097285 apoptotic process; • regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	7040
	n/a
	ENSG00000105329
	n/a
	P01137
	n/a
	NM_000660
	n/a
	NP_000651
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TGFB1 yw TGFB1 a elwir hefyd yn Transforming growth factor beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.2.^[2]

Ffeithiau sydyn Strwythurau, PDB ...

Cau

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TGFB1.

CED
LAP
DPD1
TGFB
TGFbeta

"TGF-β1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer. ". Cancer Lett. 2018. PMID 29079415.
"The c.29T>C polymorphism of the transforming growth factor beta-1 (TGFB1) gene, bone mineral density and the occurrence of low-energy fractures in patients with inflammatory bowel disease. ". Mol Biol Rep. 2017. PMID 28993955.
"Loss of regulatory characteristics in CD4+ CD25+/hi T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis. ". APMIS. 2017. PMID 28913840.
"TGF-β signaling is an effective target to impair survival and induce apoptosis of human cholangiocarcinoma cells: A study on human primary cell cultures. ". PLoS One. 2017. PMID 28873435.
"Transmission analysis of TGFB1 gene polymorphisms in non-syndromic cleft lip with or without cleft palate.". Int J Pediatr Otorhinolaryngol. 2017. PMID 28802359.

[1] [1]
"Human PubMed Reference:".

[2] [2]
TGFB1 - Cronfa NCBI

[2]

[1]

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