Protein sy'n cael ei godio yn y corff dynol gan y genyn MEF2D yw MEF2D a elwir hefyd yn Myocyte enhancer factor 2D (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q22.[2]
Ffeithiau sydyn Dynodwyr, Cyfenwau ...
| MEF2D |
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| Dynodwyr |
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| Cyfenwau | MEF2D, myocyte enhancer factor 2D |
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| Dynodwyr allanol | OMIM: 600663 HomoloGene: 4327 GeneCards: MEF2D |
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| Ontoleg y genyn |
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| Gweithrediad moleciwlaidd | • DNA binding
• protein dimerization activity
• protein homodimerization activity
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• histone deacetylase binding
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001948, GO:0016582 protein binding
• protein heterodimerization activity
• enzyme binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
|
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| Cydrannau o'r gell | • cytoplasm
• intracellular membrane-bounded organelle
• nucleoplasm
• cnewyllyn cell
|
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| Prosesau biolegol | • cell differentiation
• GO:0009373 regulation of transcription, DNA-templated
• chondrocyte differentiation
• adult heart development
• muscle organ development
• endochondral ossification
• transcription by RNA polymerase II
• transcription, DNA-templated
• nervous system development
• multicellular organism development
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• osteoblast differentiation
• skeletal muscle cell differentiation
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• GO:0097285 apoptotic process
• positive regulation of vascular associated smooth muscle cell proliferation
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| Sources:Amigo / QuickGO |
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| Orthologau |
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| Species | Bod dynol | Llygoden |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Lleoliad (UCSC) | n/a | n/a |
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| PubMed search | [1] | n/a |
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| Wicidata |
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Cau
- "Myocyte enhancer factor 2D provides a cross-talk between chronic inflammation and lung cancer. ". J Transl Med. 2017. PMID 28340574.
- "Myocyte enhancer factor 2D promotes tumorigenicity in malignant glioma cells. ". Tumour Biol. 2016. PMID 26234765.
- "MEF2D overexpression contributes to the progression of osteosarcoma. ". Gene. 2015. PMID 25814384.
- "miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D. ". Oncol Rep. 2015. PMID 25812649.
- "Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes.". Cancer Res. 2014. PMID 24390737.
