Protein sy'n cael ei godio yn y corff dynol gan y genyn LMO2 yw LMO2 a elwir hefyd yn LIM domain only 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.[2]
Ffeithiau sydyn Strwythurau, PDB ...
| LMO2 |
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| Strwythurau |
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| PDB | Human UniProt search: PDBe RCSB |
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| Dynodwyr |
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| Cyfenwau | LMO2, RBTN2, RBTNL1, RHOM2, TTG2, LIM domain only 2, LMO-2 |
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| Dynodwyr allanol | OMIM: 180385 HomoloGene: 4072 GeneCards: LMO2 |
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| Ontoleg y genyn |
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| Gweithrediad moleciwlaidd | • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• bHLH transcription factor binding
• E-box binding
• GO:0001948, GO:0016582 protein binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• metal ion binding
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| Cydrannau o'r gell | • cnewyllyn cell
• transcription regulator complex
• nucleoplasm
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| Prosesau biolegol | • multicellular organism development
• mRNA transcription by RNA polymerase II
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• cellular response to thyroid hormone stimulus
• regulation of hematopoietic stem cell differentiation
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| Sources:Amigo / QuickGO |
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| Orthologau |
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| Species | Bod dynol | Llygoden |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Lleoliad (UCSC) | n/a | n/a |
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| PubMed search | [1] | n/a |
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| Wicidata |
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Cau
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LMO2.
- TTG2
- LMO-2
- RBTN2
- RHOM2
- RBTNL1
- "LMO2-negative Expression Predicts the Presence of MYC Translocations in Aggressive B-Cell Lymphomas. ". Am J Surg Pathol. 2017. PMID 28288039.
- "Activation of the LMO2oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. ". Blood. 2017. PMID 28270453.
- "Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms. ". Exp Hematol. 2016. PMID 27302866.
- "LMO2 Is a Specific Marker of T-Lymphoblastic Leukemia/Lymphoma. ". Am J Clin Pathol. 2016. PMID 26796495.
- "The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.". Cell Death Differ. 2015. PMID 25721045.
