Protein sy'n cael ei godio yn y corff dynol gan y genyn KDM5D yw KDM5D a elwir hefyd yn Lysine demethylase 5D (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom Y dynol, band Yq11.223.[2]
Ffeithiau sydyn Strwythurau, PDB ...
| KDM5D |
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| Strwythurau |
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| PDB | Human UniProt search: PDBe RCSB |
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| Dynodwyr |
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| Cyfenwau | KDM5D, HY, HYA, JARID1D, SMCY, lysine demethylase 5D |
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| Dynodwyr allanol | OMIM: 426000 HomoloGene: 55838 GeneCards: KDM5D |
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| Ontoleg y genyn |
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| Gweithrediad moleciwlaidd | • histone H3-methyl-lysine-4 demethylase activity
• DNA binding
• oxidoreductase activity
• dioxygenase activity
• metal ion binding
• histone demethylase activity
• androgen receptor binding
• GO:0001948, GO:0016582 protein binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• chromatin binding
• histone H3-tri/di/monomethyl-lysine-4 demethylase activity
• methylated histone binding
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| Cydrannau o'r gell | • cnewyllyn cell
• nucleoplasm
• fibrillar center
• cydran cellog
• histone methyltransferase complex
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| Prosesau biolegol | • histone H3-K4 demethylation
• T cell antigen processing and presentation
• transcription, DNA-templated
• GO:0009373 regulation of transcription, DNA-templated
• regulation of androgen receptor signaling pathway
• GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• GO:1901227 negative regulation of transcription by RNA polymerase II
• histone H3-K4 demethylation, trimethyl-H3-K4-specific
• chromatin remodeling
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| Sources:Amigo / QuickGO |
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| Orthologau |
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| Species | Bod dynol | Llygoden |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Lleoliad (UCSC) | n/a | n/a |
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| PubMed search | [1] | n/a |
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| Wicidata |
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Cau
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KDM5D.
- "H-Y incompatibility predicts short-term outcomes for kidney transplant recipients. ". J Am Soc Nephrol. 2009. PMID 19541808.
- "Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus. ". Biol Reprod. 2007. PMID 16988213.
- "JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis. ". Cancer Res. 2016. PMID 26747897.
- "Investigation of Histone Lysine-Specific Demethylase 5D KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach. ". Iran Biomed J. 2016. PMID 26728332.
- "Two Splice Variants of Y Chromosome-Located Lysine-Specific Demethylase 5D Have Distinct Function in Prostate Cancer Cell Line (DU-145).". J Proteome Res. 2015. PMID 26215926.
