KCNJ12

Protein sy'n cael ei godio yn y corff dynol gan y genyn KCNJ12 yw KCNJ12 a elwir hefyd yn Potassium voltage-gated channel subfamily J member 12 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p11.2.^[2]

KCNJ12
Dynodwyr
Cyfenwau	KCNJ12, IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x, potassium voltage-gated channel subfamily J member 12, potassium inwardly rectifying channel subfamily J member 12
Dynodwyr allanol	OMIM: 602323 HomoloGene: 7793 GeneCards: KCNJ12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • inward rectifier potassium channel activity • voltage-gated ion channel activity • G-protein activated inward rectifier potassium channel activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • integral component of membrane • intrinsic component of membrane • Cellbilen • integral component of plasma membrane • bilen Prosesau biolegol • potassium ion transport • regulation of ion transmembrane transport • muscle contraction • regulation of heart contraction • protein homotetramerization • cludo ïon • potassium ion import across plasma membrane • cardiac conduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3768	n/a
Ensembl	ENSG00000184185	n/a
UniProt	Q14500	n/a
RefSeq (mRNA)	NM_021012	n/a
RefSeq (protein)	NP_066292	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KCNJ12.

• IRK2
• hIRK
• IRK-2
• hIRK1
• KCNJN1
• Kir2.2
• Kir2.2v
• kcnj12x
• hkir2.2x

Llyfryddiaeth

• "Whole exome sequencing identifies a KCNJ12 mutation as a cause of familial dilated cardiomyopathy. ". Medicine (Baltimore). 2017. PMID 28816949.
• "Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease. ". J Immunol. 2015. PMID 26324774.
• "Altered expression of genes for Kir ion channels in dilated cardiomyopathy. ". Can J Physiol Pharmacol. 2013. PMID 23889090.
• "Knockdown of inwardly rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence. ". Mol Cancer Ther. 2010. PMID 20841375.
• "Kir 2.2 inward rectifier potassium channels are inhibited by an endogenous factor in Xenopus oocytes independently from the action of a mitochondrial uncoupler.". J Cell Physiol. 2009. PMID 19016473.

Cyfeiriadau

1. "Human PubMed Reference:".
2. KCNJ12 - Cronfa NCBI