IRF4

Protein sy'n cael ei godio yn y corff dynol gan y genyn IRF4 yw IRF4 a elwir hefyd yn Interferon regulatory factor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p25.3.^[2]

IRF4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DLL
Dynodwyr
Cyfenwau	IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
Dynodwyr allanol	OMIM: 601900 HomoloGene: 1842 GeneCards: IRF4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein-lysine N-methyltransferase activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytosol • bilen • nucleoplasm • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • interferon-gamma-mediated signaling pathway • regulation of T-helper cell differentiation • myeloid dendritic cell differentiation • transcription, DNA-templated • T-helper 17 cell lineage commitment • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • peptidyl-lysine methylation • negative regulation of toll-like receptor signaling pathway • type I interferon signaling pathway • histone H3 acetylation • histone H4 acetylation • positive regulation of DNA binding • T cell activation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • defense response to protozoan • protein methylation • transcription by RNA polymerase II • cytokine-mediated signaling pathway • positive regulation of cold-induced thermogenesis • immune system process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3662	n/a
Ensembl	ENSG00000137265	n/a
UniProt	Q15306	n/a
RefSeq (mRNA)	NM_001195286 NM_002460	n/a
RefSeq (protein)	NP_001182215 NP_002451	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IRF4.

• MUM1
• LSIRF
• SHEP8
• NF-EM5

Llyfryddiaeth

• "The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate. ". Immunity. 2017. PMID 28930660.
• "Prognostic significance of interferon regulating factor 4 (IRF4) in node-negative breast cancer. ". J Cancer Res Clin Oncol. 2017. PMID 28251349.
• "IRF4 rs12203592 functional variant and melanoma survival. ". Int J Cancer. 2017. PMID 28103633.
• "Prognostic Impact of MUM1/IRF4 Expression in Burkitt Lymphoma (BL): A Reappraisal of 88 BL Patients in Japan. ". Am J Surg Pathol. 2017. PMID 28079574.
• "Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies.". Arthritis Rheumatol. 2016. PMID 27111665.

Cyfeiriadau

1. "Human PubMed Reference:".
2. IRF4 - Cronfa NCBI