Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4EBP1 yw EIF4EBP1 a elwir hefyd yn Eukaryotic translation initiation factor 4E binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p11.23.[2]
Ffeithiau sydyn Strwythurau, PDB ...
EIF4EBP1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/75/PDB_1wkw_EBI.jpg/250px-PDB_1wkw_EBI.jpg) |
Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Rhestr o ddynodwyr PDB |
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1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV |
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Dynodwyr |
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Cyfenwau | EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1 |
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Dynodwyr allanol | OMIM: 602223 HomoloGene: 3021 GeneCards: EIF4EBP1 |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Cau
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4EBP1.
- "Increased phosphorylation of 4E‑binding protein 1 predicts poor prognosis for patients with colorectal cancer. ". Mol Med Rep. 2017. PMID 28339030.
- "Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. ". Cancer Lett. 2016. PMID 27343979.
- "Phosphorylated 4EBP1 is associated with tumor progression and poor prognosis in Xp11.2 translocation renal cell carcinoma. ". Sci Rep. 2016. PMID 27026382.
- "4E-BP1, a multifactor regulated multifunctional protein. ". Cell Cycle. 2016. PMID 26901143.
- "Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors.". Sci Signal. 2015. PMID 26577921.