EGF

Protein sy'n cael ei godio yn y corff dynol gan y genyn EGF yw EGF a elwir hefyd yn Epidermal growth factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q25.^[2]

EGF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IVO, 1JL9, 1NQL, 1P9J, 2KV4, 3NJP
Dynodwyr
Cyfenwau	EGF, HOMG4, URG, epidermal growth factor, epithelial growth factor
Dynodwyr allanol	OMIM: 131530 HomoloGene: 1483 GeneCards: EGF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • transmembrane receptor protein tyrosine kinase activator activity • epidermal growth factor receptor binding • Wnt-protein binding • GO:0001948, GO:0016582 protein binding • growth factor activity • Wnt-activated receptor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cydrannau o'r gell • integral component of membrane • bilen • receptor complex • extracellular region • lysosomal membrane • extracellular exosome • platelet alpha granule lumen • extracellular space • clathrin-coated vesicle membrane • Cellbilen Prosesau biolegol • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of MAP kinase activity • epidermal growth factor receptor signaling pathway • regulation of protein localization to cell surface • ERK1 and ERK2 cascade • platelet degranulation • regulation of calcium ion import • mammary gland alveolus development • MAPK cascade • DNA replication • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of secretion • positive regulation of hyaluronan biosynthetic process • positive regulation of peptidyl-threonine phosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • angiogenesis • Wnt signaling pathway involved in dorsal/ventral axis specification • positive regulation of cell population proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of cerebellar granule cell precursor proliferation • canonical Wnt signaling pathway • negative regulation of cholesterol efflux • peptidyl-tyrosine phosphorylation • positive regulation of DNA binding • positive regulation of phosphorylation • positive regulation of mitotic nuclear division • branching morphogenesis of an epithelial tube • GO:0072468 signal transduction • regulation of peptidyl-tyrosine phosphorylation • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • positive regulation of protein tyrosine kinase activity • activation of transmembrane receptor protein tyrosine kinase activity • regulation of cell motility • positive regulation of receptor internalization • positive regulation of epidermal growth factor-activated receptor activity • membrane organization • negative regulation of ERBB signaling pathway • embryonic retina morphogenesis in camera-type eye • GO:1901313 positive regulation of gene expression • positive regulation of cell migration • positive regulation of protein kinase B signaling • negative regulation of Notch signaling pathway • regulation of receptor signaling pathway via JAK-STAT • positive regulation of canonical Wnt signaling pathway • positive regulation of protein localization to early endosome Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1950	n/a
Ensembl	ENSG00000138798	n/a
UniProt	P01133	n/a
RefSeq (mRNA)	NM_001178130 NM_001178131 NM_001963 NM_001357021	n/a
RefSeq (protein)	NP_001171601 NP_001171602 NP_001954 NP_001343950	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EGF.

• URG
• HOMG4

Llyfryddiaeth

• "Epidermal growth factor promotes proliferation and maintains multipotency of continuous cultured adipose stem cells via activating STAT signal pathway in vitro. ". Medicine (Baltimore). 2017. PMID 28746211.
• "Salivary epidermal growth factor correlates with hospitalization length in rotavirus infection. ". BMC Infect Dis. 2017. PMID 28558652.
• "Genetic Polymorphism of Epidermal Growth Factor rs4444903 Influences Susceptibility to HCV-Related Liver Cirrhosis and Hepatocellular Carcinoma in a Chinese Han Population. ". Clin Lab. 2017. PMID 28397482.
• "Transgenic Soybean Production of Bioactive Human Epidermal Growth Factor (EGF). ". PLoS One. 2016. PMID 27314851.
• "Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study.". Clin Transplant. 2016. PMID 26854475.

Cyfeiriadau

1. "Human PubMed Reference:".
2. EGF - Cronfa NCBI