CXCL8

Protein sy'n cael ei godio yn y corff dynol gan y genyn CXCL8 yw CXCL8 a elwir hefyd yn C-X-C motif chemokine ligand 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q13.3.^[2]

CXCL8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX
Dynodwyr
Cyfenwau	CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8
Dynodwyr allanol	OMIM: 146930 HomoloGene: 47937 GeneCards: CXCL8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • GO:0001948, GO:0016582 protein binding • interleukin-8 receptor binding • chemokine activity Cydrannau o'r gell • extracellular region • intracellular anatomical structure • extracellular space Prosesau biolegol • G protein-coupled receptor signaling pathway • GO:0007243 intracellular signal transduction • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • receptor internalization • cellular response to fibroblast growth factor stimulus • response to endoplasmic reticulum stress • positive regulation of angiogenesis • regulation of single stranded viral RNA replication via double stranded DNA intermediate • PERK-mediated unfolded protein response • induction of positive chemotaxis • chemotaxis • regulation of cell adhesion • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • cellular response to interleukin-1 • angiogenesis • positive regulation of neutrophil chemotaxis • inflammatory response • negative regulation of G protein-coupled receptor signaling pathway • response to molecule of bacterial origin • cellular response to lipopolysaccharide • embryonic digestive tract development • GO:0072468 signal transduction • negative regulation of cell population proliferation • calcium-mediated signaling • regulation of entry of bacterium into host cell • defense response • neutrophil chemotaxis • neutrophil activation • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • cytokine-mediated signaling pathway • leukocyte chemotaxis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3576	n/a
Ensembl	ENSG00000169429	n/a
UniProt	P10145	n/a
RefSeq (mRNA)	NM_000584 NM_001354840	n/a
RefSeq (protein)	NP_000575 NP_001341769	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CXCL8.

• IL8
• NAF
• GCP1
• LECT
• LUCT
• NAP1
• GCP-1
• LYNAP
• MDNCF
• MONAP
• NAP-1

Llyfryddiaeth

• "Streptococcus gordonii lipoproteins induce IL-8 in human periodontal ligament cells. ". Mol Immunol. 2017. PMID 28963931.
• "Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model. ". Int J Cancer. 2018. PMID 28949016.
• "CXCL8 promotes the invasion of human osteosarcoma cells by regulation of PI3K/Akt signaling pathway. ". APMIS. 2017. PMID 28736978.
• "Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis. ". Medicine (Baltimore). 2017. PMID 28562542.
• "IL-8 -251A/T polymorphism contributes to coronary artery disease susceptibility in a Chinese population.". Genet Mol Res. 2017. PMID 28218776.

Cyfeiriadau

1. "Human PubMed Reference:".
2. CXCL8 - Cronfa NCBI