C1S

Protein sy'n cael ei godio yn y corff dynol gan y genyn C1S yw C1S a elwir hefyd yn Complement C1s subcomponent a Complement C1s (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.31.^[2]

C1S
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ELV, 1NZI, 4J1Y, 4LMF, 4LOR, 4LOS, 4LOT
Dynodwyr
Cyfenwau	C1S, EDSPD2, complement C1s
Dynodwyr allanol	OMIM: 120580 HomoloGene: 1314 GeneCards: C1S
EC number	3.4.21.42
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • GO:0070122 peptidase activity • serine-type peptidase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • metal ion binding • identical protein binding • serine-type endopeptidase activity Cydrannau o'r gell • blood microparticle • extracellular exosome • extracellular region • extracellular space Prosesau biolegol • proteolysis • complement activation, classical pathway • immune system process • innate immune response • complement activation, lectin pathway • complement activation • regulation of complement activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	716	n/a
Ensembl	ENSG00000182326	n/a
UniProt	P09871	n/a
RefSeq (mRNA)	NM_001734 NM_201442 NM_001346850	n/a
RefSeq (protein)	NP_001333779 NP_001725 NP_958850	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn C1S.

• EDSPD2

Llyfryddiaeth

• "TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. ". Blood. 2014. PMID 24695853.
• "Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice. ". Nephron Exp Nephrol. 2013. PMID 23989031.
• "Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. ". J Immunol. 2012. PMID 22855709.
• "Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene. ". Mol Immunol. 2008. PMID 18062908.
• "Elucidation of the substrate specificity of the C1s protease of the classical complement pathway.". J Biol Chem. 2005. PMID 16169853.

Cyfeiriadau

1. "Human PubMed Reference:".
2. C1S - Cronfa NCBI