BMPR1A

Protein sy'n cael ei godio yn y corff dynol gan y genyn BMPR1A yw BMPR1A a elwir hefyd yn Bone morphogenetic protein receptor type 1A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.2.^[2]

BMPR1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3QB4, 1ES7, 1REW, 2GOO, 2H62, 2H64, 2K3G, 2QJ9, 2QJA, 2QJB, 3NH7
Dynodwyr
Cyfenwau	BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, bone morphogenetic protein receptor type 1A
Dynodwyr allanol	OMIM: 601299 HomoloGene: 20911 GeneCards: BMPR1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • SMAD binding • ATP binding • BMP receptor activity • transforming growth factor beta-activated receptor activity • transforming growth factor beta receptor activity, type I • growth factor binding Cydrannau o'r gell • integral component of membrane • HFE-transferrin receptor complex • bilen • Cellbilen • neuronal cell body • dendrite • caveola • external side of plasma membrane • integral component of plasma membrane • receptor complex • cell surface Prosesau biolegol • somitogenesis • pattern specification process • roof of mouth development • cell differentiation • pituitary gland development • endoderm development • chondrocyte differentiation • neural crest cell development • lateral mesoderm development • lung development • positive regulation of bone mineralization • embryonic organ development • paraxial mesoderm structural organization • positive regulation of epithelial cell proliferation • phosphorylation • negative regulation of neurogenesis • positive regulation of pathway-restricted SMAD protein phosphorylation • mesoderm formation • ectoderm development • embryonic digit morphogenesis • heart morphogenesis • cellular response to BMP stimulus • in utero embryonic development • BMP signaling pathway • hindlimb morphogenesis • nervous system development • dorsal/ventral axis specification • regulation of lateral mesodermal cell fate specification • stem cell population maintenance • odontogenesis of dentin-containing tooth • Mullerian duct regression • endocardial cushion formation • protein phosphorylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • cartilage development • positive regulation of osteoblast differentiation • developmental growth • transmembrane receptor protein serine/threonine kinase signaling pathway • positive regulation of mesenchymal cell proliferation • heart formation • neural plate pattern specification • embryonic morphogenesis • mesendoderm development • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of cellular senescence • neural plate mediolateral regionalization • dorsal/ventral pattern formation • transforming growth factor beta receptor signaling pathway • positive regulation of SMAD protein signal transduction • anterior/posterior pattern specification • paraxial mesoderm development • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of smooth muscle cell migration • BMP signaling pathway involved in heart development • regulation of cardiac muscle cell apoptotic process • outflow tract septum morphogenesis • outflow tract morphogenesis • cardiac conduction system development • mitral valve morphogenesis • tricuspid valve morphogenesis • endocardial cushion morphogenesis • cardiac right ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • ventricular compact myocardium morphogenesis • dorsal aorta morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of cardiac muscle cell proliferation • positive regulation of cardiac muscle cell proliferation • pharyngeal arch artery morphogenesis • positive regulation of cardiac ventricle development • positive regulation of vascular associated smooth muscle cell proliferation • fibrous ring of heart morphogenesis • regulation of neural crest cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	657	n/a
Ensembl	ENSG00000107779	n/a
UniProt	P36894	n/a
RefSeq (mRNA)	NM_004329	n/a
RefSeq (protein)	NP_004320	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BMPR1A.

• ALK3
• SKR5
• CD292
• ACVRLK3
• 10q23del

Llyfryddiaeth

• "Enrichment of Adipose-Derived Stromal Cells for BMPR1A Facilitates Enhanced Adipogenesis. ". Tissue Eng Part A. 2016. PMID 26585335.
• "Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. ". Oncotarget. 2015. PMID 26274893.
• "Identification of coding exon 3 duplication in the BMPR1A gene in a patient with juvenile polyposis syndrome. ". Jpn J Clin Oncol. 2014. PMID 25129392.
• "Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. ". Br J Cancer. 2013. PMID 23969729.
• "Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines.". PLoS One. 2013. PMID 23593444.

Cyfeiriadau

1. "Human PubMed Reference:".
2. BMPR1A - Cronfa NCBI