ZFY

Y-hromosomski protein cinkovog prsta je protein koju je kod ljudi kodiran genom ZFY Y-hromosoma.^[3][4]

ZFY
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 1KLR, 1KLS, 1XRZ, 5ZNF
Identifikatori
Aliasi	ZFY
Vanjski ID-jevi	OMIM: 490000 HomoloGene: 88465 GeneCards: ZFY
Lokacija gena (čovjek) Hrom. Hromosom Y[1] Bend Yp11.2 Početak 2,935,281 bp[1] Kraj 2,982,506 bp[1]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro • nukleoplazma • Jedarce Biološki proces • multicellular organism development • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7544	n/a
Ensembl	ENSG00000067646	n/a
UniProt	P08048	n/a
RefSeq (mRNK)	NM_001145275 NM_001145276 NM_003411	n/a
RefSeq (bjelančevina)	NP_001138747 NP_001138748 NP_003402 NP_001356631 NP_001356632 NP_001356633 NP_001356634 NP_001356635 NP_001356636 NP_001356637 NP_001356638 NP_001356639	n/a
Lokacija (UCSC)	Chr Y: 2.94 – 2.98 Mb	n/a
PubMed pretraga	[2]	n/a
Wikipodaci
Pogledaj/uredi – čovjek

Ovaj gen kodira cinkov prst-sadržavajući protein, koji može funkcionirati kao faktor transkripcije. Ovaj gen je nekoć bio kandidat za gen za tzv. testis-determinirajući faktor (TDF) i pogrešno je označen kao TDF.^[4]

Ljudi eksprimiraju jedan ZFY gen sa dvije prerade. Dok miševi imaju dvije paralogne kopije, Zfy1 i Zfy2. .^[5] Tokom spermatogeneze, pogrešno ispoljavanje bilo Zfy1, bilo Zfy2, rezultira programiranom ćelijskom smrću, apoptozama, na kontrolnoj tački srednjieg pahitena. U miševa su geni Zfy, neophodni za inaktivaciju mejotkog spolnog hromosoma (MSCI). U Zfy nokaut spermatocitima, spolni hromosomi se pogrešno utišavaju. Dakle, na kontrolnoj tački srednjeg pahitina, Zfy obavlja tri funkcije: (1) promovira MSCI, (2) prati napredak MSCI-a i (3) uništava ćelije apoptozom, koje ne prolaze MSCI.^[5]

ZFY se kod ljudi najšire ispojava u testisima i prostati. Međutim, 20 drugih tkiva također eksprimiraju ZFY, kao što su jednjak, mokraćna bešika, koštana srž, tanko crijevo, slijepo crijevo i žučna kesa.^[6]

Poremećaji povezani sa ZFY genom uključuju bolesti kao što su kampomelna displazija, cistadenofibrom i Frasierov sindrom.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000067646 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Müller G, Schempp W (april 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Human Genetics. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060.
4. "Entrez Gene: ZFY zinc finger protein, Y-linked".
5. Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJ (decembar 2016). "Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes". Human Molecular Genetics. 25 (24): 5300–5310. doi:10.1093/hmg/ddw344. PMC 5418838. PMID 27742779.
6. "ZFY Gene". GeneCards. Pristupljeno 15. 4. 2019.
7. "MalaCards: Search Human Diseases - ZFY". Mala Cards. Pristupljeno 15. 4. 2019.

Dopunska literatura

• Merchant-Larios H, Moreno-Mendoza N (2002). "Onset of sex differentiation: dialog between genes and cells". Archives of Medical Research. 32 (6): 553–8. doi:10.1016/S0188-4409(01)00317-4. PMID 11750730.
• Kochoyan M, Havel TF, Nguyen DT, Dahl CE, Keutmann HT, Weiss MA (april 1991). "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition". Biochemistry. 30 (14): 3371–86. doi:10.1021/bi00228a004. PMID 1849423.
• Kochoyan M, Keutmann HT, Weiss MA (juli 1991). "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition". Biochemistry. 30 (29): 7063–72. doi:10.1021/bi00243a005. PMID 1854720.
• North M, Sargent C, O'Brien J, Taylor K, Wolfe J, Affara NA, Ferguson-Smith MA (maj 1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY". Nucleic Acids Research. 19 (10): 2579–86. doi:10.1093/nar/19.10.2579. PMC 328173. PMID 2041734.
• Palmer MS, Berta P, Sinclair AH, Pym B, Goodfellow PN (mart 1990). "Comparison of human ZFY and ZFX transcripts". Proceedings of the National Academy of Sciences of the United States of America. 87 (5): 1681–5. Bibcode:1990PNAS...87.1681P. doi:10.1073/pnas.87.5.1681. PMC 53546. PMID 2308929.
• Affara NA, Chambers D, O'Brien J, Habeebu SS, Kalaitsidaki M, Bishop CE, Ferguson-Smith MA (april 1989). "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9". Nucleic Acids Research. 17 (8): 2987–99. doi:10.1093/nar/17.8.2987. PMC 317707. PMID 2498838.
• Lau YF, Chan KM (decembar 1989). "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues". American Journal of Human Genetics. 45 (6): 942–52. PMC 1683462. PMID 2511751.
• Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG (decembar 1987). "The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): 1091–104. doi:10.1016/0092-8674(87)90595-2. PMID 3690661.
• Tricoli JV, Bracken RB (februar 1993). "ZFY gene expression and retention in human prostate adenocarcinoma". Genes, Chromosomes & Cancer. 6 (2): 65–72. doi:10.1002/gcc.2870060202. PMID 7680890.
• Erlandsson R, Wilson JF, Pääbo S (maj 2000). "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans". Molecular Biology and Evolution. 17 (5): 804–12. doi:10.1093/oxfordjournals.molbev.a026359. PMID 10779541.
• Mittwoch U (2001). "Three thousand years of questioning sex determination". Cytogenetics and Cell Genetics. 91 (1–4): 186–91. doi:10.1159/000056842. PMID 11173854.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC (juni 2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
• Agate RJ, Choe M, Arnold AP (februar 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.