RRAGB

Ras-srodni GTP-vezulući protein B je protein koji je kod ljudi kodiran genom RRAGB.^[4][5][6]

RRAGB
Identifikatori
Aliasi	RRAGB
Vanjski ID-jevi	OMIM: 300725 MGI: 3038613 HomoloGene: 48396 GeneCards: RRAGB
Lokacija gena (miš) Hrom. Hromosom X (miš)[1] Bend X|X F3 Početak 151,922,977 bp[1] Kraj 151,954,939 bp[1]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • GTP binding • GO:0001948, GO:0016582 vezivanje za proteine • guanyl ribonucleotide binding • GO:0006184 GTPase activity • protein heterodimerization activity • GTPase binding Ćelijska komponenta • citoplazma • citosol • lysosomal membrane • Lizozom • jedro • Gtr1-Gtr2 GTPase complex Biološki proces • regulation of TOR signaling • cellular response to amino acid starvation • cellular response to amino acid stimulus • positive regulation of TOR signaling • regulation of autophagy • regulation of macroautophagy • positive regulation of TORC1 signaling • cellular response to leucine starvation • cellular response to starvation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10325	245670
Ensembl	ENSG00000083750	ENSMUSG00000041658
UniProt	Q5VZM2	Q6NTA4
RefSeq (mRNK)	NM_006064 NM_016656	NM_001004154
RefSeq (bjelančevina)	NP_006055 NP_057740 NP_001340940 NP_001340942	NP_001004154
Lokacija (UCSC)	n/a	Chr X: 151.92 – 151.95 Mb
PubMed pretraga	[2]	[3]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ras-homologne GTPaze čine veliku porodicu pretvarača signala koji se izmjenjuju između aktiviranog, GTP-vezujućeg i inaktiviranog, GDP-vezujućeg stanja. Ti proteini predstavljaju ćelijske preklopnike kojima upravljaju faktori GTP-razmjene i faktori koji stimuliraju njihovu unutrašnju aktivnost GTPaza. Svim GTPazama superporodice Ras zajedničko je prisustvo šest konzerviranih motiva, uključenih u vezanje GTP/GDP, od kojih su tri mjesta za vezanje fosfata/magnezija (PM1-PM3) i od kojih su tri guaninska mjesta za vezanje nukleotida (G1-G3). Utvrđene su varijante transkripta koje kodiraju različite izoforme. MTORC1 reaguje na aminokiseline, interakcijom sa RAGB.^[6]

Reference

1. GRCm38: Ensembl release 89: ENSMUSG00000041658 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
5. Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111. ( Pt 1): 11–21. PMID 9394008.
6. "Entrez Gene: RRAGB Ras-related GTP binding B".

Dopunska literatura

• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. doi:10.1167/iovs.02-1099. PMID 12766061.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B." J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.