MikroRNK 7-1 je mikroRNK molekula koja je kodirana genom MIR7-1.[3]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
mikroRNK ili miRNA su kratke (20-24 nukleotidne) nekodirajuće RNK koje su uključene u post-transkripcijsku regulaciju ekspresije gena u višećelijskih organizama utičući i na stabilnost i na translaciju iRNK. miRNK se transkribiraju RNK-polimerazom II kao dio pokrivenih i poliadeniliranih primarnih transkripata (pre-miRNK) koje mogu biti protein-kodirajuće ili nekodirajuće. Primarni transkript cijepa enzim Drosha ribonukleaza III, da bi se proizvela približno 70-nt prekursorna miRNK iz matične petlje (pre-miRNK), koju dalje cijepa citoplazmatska Dicer ribonukleaza, kako bi nastali proizvodi zrela miRNK i antisens miRNK zvjezdica (miRNK*). Zrela miRNK je inkorporirana u RNK-inducirani kompleks za utišavanje (RISC), koji prepoznaje ciljane iRNK, putem nesavršenog uparivanja baza s miRNK i najčešće rezultira translacijskom inhibicijom ili destabilizacijom ciljane iRNK. RefSeq predstavlja predviđenu matičnu petlju mikroRNK (obezbedio RefSeq, septembar 2009).
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