MAGEA2

Melanom-pridružni antigen 2 je protein koji je kod ljudi kodiran genom MAGEA2.^[3][4][5]

MAGEA2
Identifikatori
Aliasi	MAGEA2
Vanjski ID-jevi	OMIM: 300173 HomoloGene: 18781 GeneCards: MAGEA2
Lokacija gena (čovjek) Hrom. Hromosom X[1] Bend Xq28 Početak 152,749,863 bp[1] Kraj 152,753,884 bp[1]
Ontologija gena Molekularna funkcija • histone deacetylase binding • GO:0001948, GO:0016582 vezivanje za proteine • ubiquitin protein ligase binding Ćelijska komponenta • PML body • jedro Biološki proces • signal transduction by p53 class mediator • Ćelijsko starenje • negative regulation of protein sumoylation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of ubiquitin-protein transferase activity • transcription, DNA-templated • negative regulation of protein acetylation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4101	n/a
Ensembl	ENSG00000268606	n/a
UniProt	P43356	n/a
RefSeq (mRNK)	NM_001282501 NM_001282502 NM_001282504 NM_001282505 NM_005361 NM_175742 NM_175743 NM_001386130	n/a
RefSeq (bjelančevina)	NP_001269430 NP_001269431 NP_001269433 NP_001269434 NP_005352 NP_786884 NP_786885	n/a
Lokacija (UCSC)	Chr X: 152.75 – 152.75 Mb	n/a
PubMed pretraga	[2]	n/a
Wikipodaci
Pogledaj/uredi – čovjek

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000268606 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7. doi:10.1126/science.1840703. PMID 1840703.
4. Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
5. "Entrez Gene: MAGEA2 melanoma antigen family A, 2".

Dopunska literatura

• Brasseur F, Rimoldi D, Liénard D, et al. (1995). "Expression of MAGE genes in primary and metastatic cutaneous melanoma". Int. J. Cancer. 63 (3): 375–80. doi:10.1002/ijc.2910630313. PMID 7591235.
• De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540.
• Gaugler B, Van den Eynde B, van der Bruggen P, et al. (1994). "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes". J. Exp. Med. 179 (3): 921–30. doi:10.1084/jem.179.3.921. PMC 2191409. PMID 8113684.
• De Smet C, Lurquin C, van der Bruggen P, et al. (1994). "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics. 39 (2): 121–9. doi:10.1007/bf00188615. PMID 8276455.
• Zakut R, Topalian SL, Kawakami Y, et al. (1993). "Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines". Cancer Res. 53 (1): 5–8. PMID 8416750.
• Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagao T, Higashitsuji H, Nonoguchi K, et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity". J. Biol. Chem. 278 (12): 10668–74. doi:10.1074/jbc.M206104200. PMID 12525503.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Monte M, Simonatto M, Peche LY, et al. (2006). "MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents". Proc. Natl. Acad. Sci. U.S.A. 103 (30): 11160–5. doi:10.1073/pnas.0510834103. PMC 1544058. PMID 16847267.
• Wischnewski F, Friese O, Pantel K, Schwarzenbach H (2007). "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters". Mol. Cancer Res. 5 (7): 749–59. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.