GRIPAP1

GRIP1-asocirani protein 1 je protein koji je kod ljudi kodiran genom GRIPAP1.^[5][6]

GRIPAP1
Identifikatori
Aliasi	GRIPAP1
Vanjski ID-jevi	OMIM: 300408 MGI: 1859616 HomoloGene: 41348 GeneCards: GRIPAP1
Lokacija gena (čovjek) Hrom. Hromosom X[1] Bend Xp11.23 Početak 48,973,720 bp[1] Kraj 49,002,264 bp[1]
Lokacija gena (miš) Hrom. Hromosom X (miš)[2] Bend X A1.1|X 3.51 cM Početak 7,656,004 bp[2] Kraj 7,686,806 bp[2]
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • molekularna funkcija Ćelijska komponenta • endozom • blood microparticle • nukleoplazma • citosol • intracellular membrane-bounded organelle • postsynaptic recycling endosome • membrana • međućelijske veze • Akson • dendrit • early endosome membrane • projekcija ćelije • sinapsa • recycling endosome membrane • glutamatergic synapse • extrinsic component of postsynaptic early endosome membrane Biološki proces • neurotransmitter receptor transport, endosome to postsynaptic membrane • regulation of modification of synaptic structure • GO:0015915 transport • protein transport • GO:0022610 biološki proces • regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane • regulation of recycling endosome localization within postsynapse Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	56850	54645
Ensembl	ENSG00000068400	ENSMUSG00000031153
UniProt	Q4V328	Q8VD04
RefSeq (mRNK)	NM_020137 NM_207672	NM_001290455 NM_207670 NM_001359289 NM_001359290 NM_001359291 NM_001359293
RefSeq (bjelančevina)	NP_064522	NP_001277384 NP_997553 NP_001346218 NP_001346219 NP_001346220 NP_001346222
Lokacija (UCSC)	Chr X: 48.97 – 49 Mb	Chr X: 7.66 – 7.69 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Funkcija

GRASP1 je faktor razmjene neuron-specifičnog guaninskoh nukleotida porodice Ras malih G proteina (RasGEF) i povezan je sa GRIP / AMPA receptorskim kompleksom u mozgu (prema OMIMu, Ye et al., 2000).^[6]

Molekulske funkcije

• GO:0001948 vezanje na proteine
• endosom
• mikročestice krvi
• nukleoplazma
• citosol
• unutarćelijska membrana ograničena organelom
• endosom za reciklažu postsinaptika
• membrana
• ćelijski spoj
• akson
• dendrit
• membrana ranih endosoma
• projiciranje ćelije
• sinapsa
• recikliranje endosomske membrane
• glutamatergička sinapsa
• ekstrinzična komponenta postsinaptičke rane endosomske membrane

Ćelijske komponente

• transport receptora neurotransmitera, endosoma do postsinapsne membrane
• regulacija modifikacije sinapsne strukture
• transport
• transport proteina
• biološki procesi
• regulacija transporta receptora neurotransmitera, endosoma do postsinaptičke membrane
• regulacija lokalizacije endosoma za reciklažu u okviru postsinapse

Interakcije

Pokazano je da GRIPAP1 ima interakcije sa GRIP1.^[5]

Reference

1. GRCh38: Ensembl release 89: ENSG00000068400 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031153 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.
6. "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

Dopunska literatura

• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP (2002). "Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex". J. Biol. Chem. 277 (4): 2396–405. doi:10.1074/jbc.M106312200. PMID 11704662.
• Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
• Ye B, Sugo N, Hurn PD, Huganir RL (2002). "Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody". Neuroscience. 114 (1): 217–27. doi:10.1016/S0306-4522(02)00142-2. PMID 12207967.
• Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
• Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes Cells. 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Stinton LM, Selak S, Fritzler MJ (2005). "Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes". Clin. Immunol. 116 (2): 108–17. doi:10.1016/j.clim.2005.03.021. PMID 15897011.