DEFB129

Beta-defenzin 129 je protein koji je kod ljudi kodiran genom DEFB129.^[5][6]

DEFB129
Identifikatori
Aliasi	DEFB129
Vanjski ID-jevi	MGI: 3644405 HomoloGene: 83411 GeneCards: DEFB129
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek)[1] Bend 20p13 Početak 227,258 bp[1] Kraj 229,886 bp[1]
Lokacija gena (miš) Hrom. Hromosom 2 (miš)[2] Bend 2|2 H1 Početak 152,300,975 bp[2] Kraj 152,306,540 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ortolozi
Vrste	Čovjek	Miš
Entrez	140881	629114
Ensembl	ENSG00000125903	ENSMUSG00000074681
UniProt	Q9H1M3	Q30KP0
RefSeq (mRNK)	NM_080831	NM_001037933
RefSeq (bjelančevina)	NP_543021	NP_001033022
Lokacija (UCSC)	Chr 20: 0.23 – 0.23 Mb	Chr 2: 152.3 – 152.31 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Defenzini su cisteinom bogati kalcitonski polipeptidi koji su važni u imundki odgovor na invaziju mikroorganizama. Protein kodiran ovim genom luči se i član je porodice beta defenzinskih proteina. Beta-defenzinski geni se nalaze u nekoliko genomskih klastera , s tim da se ovaj gen mapira u klasteru sekvence 20p13.^[6]

Reference

1. GRCh38: Ensembl release 89: ENSG00000125903 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074681 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved β-defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
6. "Entrez Gene: DEFB129 defensin, beta 129".

Dopunska literatura

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics. 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395.
• Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. CiteSeerX 10.1.1.108.7808. doi:10.1165/rcmb.2002-0205OC. PMID 12600824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.