CXCL6

Hemokinski ligand 6 (C-X-C motiv) jest mali citokin koji je kod ljudi kodiran genom CXCL6 sa hromosoma 4. Pripada porodici hemokina CXC koja je poznata i kao granulocitni hemotaksijski protein 2 (GCP-2). Kao što mu prijašnji naziv govori, CXCL6 je hemoatraktant za neutrofilne granulocite.^[5][6] Izaziva hemotaksijske efekte interakcijom sa CXCR1 CXCR1 i CXCR2.^[6] Na ljudskom hromosomu 4 gen za CXCL6 nalazi se u grupi sa drugim CXC hemokinskim genima.^[7][8]

CXCL6
Identifikatori
Aliasi	CXCL6
Vanjski ID-jevi	OMIM: 138965 MGI: 1096868 HomoloGene: 88671 GeneCards: CXCL6
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q13.3 Početak 73,836,640 bp[1] Kraj 73,849,064 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5 E1|5 44.78 cM Početak 90,907,219 bp[2] Kraj 90,909,483 bp[2]
Ontologija gena Molekularna funkcija • cytokine activity • CXCR chemokine receptor binding • heparin binding • chemokine activity • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • Hemotaksija • cell-cell signaling • chemokine-mediated signaling pathway • regulation of cell population proliferation • defense response to bacterium • GO:0072468 Transdukcija signala • neutrophil mediated immunity • defense response • positive regulation of neutrophil chemotaxis • neutrophil chemotaxis • neutrophil activation • antimicrobial humoral immune response mediated by antimicrobial peptide • cellular response to lipopolysaccharide • inflammatory response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • leukocyte homeostasis • leukocyte chemotaxis • response to lipopolysaccharide • regulation of chemokine production • regulation of neutrophil mediated killing of gram-negative bacterium Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6372	20311
Ensembl	ENSG00000124875	ENSMUSG00000029371
UniProt	P80162	P50228
RefSeq (mRNK)	NM_002993	NM_009141
RefSeq (bjelančevina)	NP_002984	NP_033167
Lokacija (UCSC)	Chr 4: 73.84 – 73.85 Mb	Chr 5: 90.91 – 90.91 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hemokinski ligand 6 (C-X-C motiv) (granulocitni hemotaksijski protein 2)
Identifikatori
Simbol	CXCL6
Alt. simboli	SCYB6, GCP-2, CKA-3
NCBI gen	6372
HGNC	10643
OMIM	138965
RefSeq	NM_002993
UniProt	P80162
Ostali podaci
Lokus	Hrom. 4 q21
Pretraga za Strukture Swiss-model Domene InterPro

Reference

1. GRCh38: Ensembl release 89: ENSG00000124875 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38): 10170–7. doi:10.1021/bi00089a037. PMID 8399143.
6. Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9): 2716–23. doi:10.1021/bi961999z. PMID 9054580.
7. Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1): 136–9. doi:10.1006/geno.1997.5100. PMID 9465307.
8. O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

Vanjski linkovi