Arrestin beta 1

Arrestin beta 1 ARRB1 kimi də adlanır — insanlarda 11-ci xromosomun qısa qolunda olan tək bir gen tərəfindən kodlanmış zülal.^[1][2]

Arrestin beta 1
Tanımlayıcılar
Digər adları	ARRB1non-visual arrestin-2beta-arrestin-1Arrestin beta-1arrestin 2
Xarici ID-lər	GeneCards:
Ortoloqlar
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Yeri (UCSC)	n/a	n/a
PubMed axtarışı	n/a	n/a
Wikidata
İnsanı göstər/redaktə et

Funksiyası

Beta-arrestin zülal ailəsinin üzvlərinin G zülalı ilə əlaqəli reseptorların agonist vasitəçiliyi ilə desensitizasiyasında iştirak etdiyi və hormonlar, neyrotransmitterlər və ya duyğu siqnalları kimi stimullara hüceyrə reaksiyalarının spesifik şəkildə yatırılmasına səbəb olduğu düşünülür.

Arrestin beta 1 sitozolik zülaldır və beta-adrenergik reseptorların beta-adrenergik reseptor^[3] kinaz (BARK)^[4] vasitəçiliyi ilə desensibilizasiyasında kofaktor kimi çıxış edir.

Arrestin beta 1 mərkəzi sinir sistemi ilə yanaşı, periferik qan leykositlərində yüksək səviyyədə ifadə edilir və beləliklə, BARK/beta-arrestin sisteminin reseptor vasitəçiliyi ilə immun funksiyalarının tənzimlənməsində böyük rol oynadığına inanılır.

Alternativ olaraq, arrestin beta 1-in müxtəlif izoformlarını kodlayan birləşdirilmiş transkriptlər təsvir edilmişdir, lakin onların dəqiq funksiyaları məlum deyil.^[2] Beta-arrestinin aralıq maddələri birləşdirən və reseptorları klatrin vasitəçiliyi ilə endositoza birləşdirərək G-protein siqnalını yönləndirə bilən bir çərçivə rolunu oynadığı göstərilir.^[5]

Qarşılıqlı əlaqələri

Arrestin beta 1 ilə qarşılıqlı əlaqədə olanlar:

• ARF6,^[6]
• PTHLH,^[7]
• DVL2^[8]
• Mdm2,^[9][10]
• OPRD1,^[11]
• PSCD2,^[6] və
• RALGDS.^[12]

İstinadlar

1. Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A. "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing". The Journal of Biological Chemistry. 268 (13). May 1993: 9753–9761. doi:10.1016/S0021-9258(18)98412-7. PMID 8486659.
2. "Entrez Gene: ARRB1 arrestin, beta 1". 2010-12-05 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
3. "Arxivlənmiş surət". 2023-08-19 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
4. "Arxivlənmiş surət". 2023-07-11 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-19.
5. Peterson YK, Luttrell LM. "The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling". Pharmacological Reviews. 69 (3). July 2017: 256–297. doi:10.1124/pr.116.013367. PMC 5482185. PMID 28626043.
6. Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". The Journal of Biological Chemistry. 276 (45). November 2001: 42509–42513. doi:10.1074/jbc.M108399200. PMID 11533043.
7. Conlan LA, Martin TJ, Gillespie MT. "The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B". FEBS Letters. 527 (1–3). September 2002: 71–75. doi:10.1016/S0014-5793(02)03164-2. PMID 12220636.
8. Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ, Miller WE. "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proceedings of the National Academy of Sciences of the United States of America. 98 (26). December 2001: 14889–14894. Bibcode:2001PNAS...9814889C. doi:10.1073/pnas.211572798. PMC 64954. PMID 11742073.
9. Wang P, Wu Y, Ge X, Ma L, Pei G. "Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus". The Journal of Biological Chemistry. 278 (13). March 2003: 11648–11653. doi:10.1074/jbc.M208109200. PMID 12538596.
10. Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM. "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor". The Journal of Biological Chemistry. 283 (32). August 2008: 22166–22176. doi:10.1074/jbc.M709668200. PMC 2494938. PMID 18544533.
11. Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, və b. "Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor". Journal of Neurochemistry. 76 (6). March 2001: 1887–1894. doi:10.1046/j.1471-4159.2001.00204.x. PMID 11259507.
12. Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, və b. "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nature Cell Biology. 4 (8). August 2002: 547–555. doi:10.1038/ncb821. PMID 12105416.

Ədəbiyyatı

• Lefkowitz RJ. "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization". The Journal of Biological Chemistry. 273 (30). July 1998: 18677–18680. doi:10.1074/jbc.273.30.18677. PMID 9668034.
• Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. "beta-Arrestin: a protein that regulates beta-adrenergic receptor function". Science. 248 (4962). June 1990: 1547–1550. Bibcode:1990Sci...248.1547L. doi:10.1126/science.2163110. PMID 2163110.
• Calabrese G, Sallese M, Stornaiuolo A, Morizio E, Palka G, De Blasi A. "Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13". Genomics. 24 (1). November 1994: 169–171. doi:10.1006/geno.1994.1594. PMID 7896272.
• Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A. "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing". The Journal of Biological Chemistry. 268 (13). May 1993: 9753–9761. doi:10.1016/S0021-9258(18)98412-7. PMID 8486659.
• Iacovelli L, Franchetti R, Masini M, De Blasi A. "GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response". Molecular Endocrinology. 10 (9). September 1996: 1138–1146. doi:10.1210/mend.10.9.8885248. PMID 8885248.
• Bonaldo MF, Lennon G, Soares MB. "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9). September 1996: 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Goodman OB, Krupnick JG, Gurevich VV, Benovic JL, Keen JH. "Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain". The Journal of Biological Chemistry. 272 (23). June 1997: 15017–15022. doi:10.1074/jbc.272.23.15017. PMID 9169477.
• Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ. "Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1". The Journal of Biological Chemistry. 272 (49). December 1997: 31051–31057. doi:10.1074/jbc.272.49.31051. PMID 9388255.
• Aragay AM, Mellado M, Frade JM, Martin AM, Jimenez-Sainz MC, Martinez-A C, Mayor F. "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2". Proceedings of the National Academy of Sciences of the United States of America. 95 (6). March 1998: 2985–2990. Bibcode:1998PNAS...95.2985A. doi:10.1073/pnas.95.6.2985. PMC 19681. PMID 9501202.
• ter Haar E, Musacchio A, Harrison SC, Kirchhausen T. "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker". Cell. 95 (4). November 1998: 563–573. doi:10.1016/S0092-8674(00)81623-2. PMC 4428171. PMID 9827808.
• Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, və b. "Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes". Science. 283 (5402). January 1999: 655–661. doi:10.1126/science.283.5402.655. PMID 9924018.
• McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. "Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation". The Journal of Biological Chemistry. 274 (16). April 1999: 10677–10680. doi:10.1074/jbc.274.16.10677. PMID 10196135.
• Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. "Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases". The Journal of Biological Chemistry. 274 (23). June 1999: 15971–15974. doi:10.1074/jbc.274.23.15971. PMID 10347142.
• McConalogue K, Déry O, Lovett M, Wong H, Walsh JH, Grady EF, Bunnett NW. "Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor". The Journal of Biological Chemistry. 274 (23). June 1999: 16257–16268. doi:10.1074/jbc.274.23.16257. PMID 10347182.
• Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ. "beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis". The Journal of Biological Chemistry. 275 (15). April 2000: 11312–11319. doi:10.1074/jbc.275.15.11312. PMID 10753943.
• Laporte SA, Oakley RH, Holt JA, Barak LS, Caron MG. "The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits". The Journal of Biological Chemistry. 275 (30). July 2000: 23120–23126. doi:10.1074/jbc.M002581200. PMID 10770944.
• Bennett TA, Maestas DC, Prossnitz ER. "Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence". The Journal of Biological Chemistry. 275 (32). August 2000: 24590–24594. doi:10.1074/jbc.C000314200. PMID 10823817.
• Shiina T, Kawasaki A, Nagao T, Kurose H. "Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors". The Journal of Biological Chemistry. 275 (37). September 2000: 29082–29090. doi:10.1074/jbc.M909757199. PMID 10862778.
• Barlic J, Andrews JD, Kelvin AA, Bosinger SE, DeVries ME, Xu L, və b. "Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI". Nature Immunology. 1 (3). September 2000: 227–233. doi:10.1038/79767. PMID 10973280.
• Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, və b. "Visualization of arrestin recruitment by a G-protein-coupled receptor". Nature. 512 (7513). August 2014: 218–222. Bibcode:2014Natur.512..218S. doi:10.1038/nature13430. PMC 4134437. PMID 25043026.

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