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Zinc uptake regulator
Bacterial gene / From Wikipedia, the free encyclopedia
The zinc uptake regulator (Zur) gene is a bacterial gene that codes for a transcription factor protein involved in zinc homeostasis. The protein is a member of the ferric uptake regulator family and binds zinc with high affinity. It typically functions as a repressor of zinc uptake proteins via binding to characteristic promoter DNA sequences in a dimer-of-dimers arrangement that creates strong cooperativity.[1] Under conditions of zinc deficiency, the protein undergoes a conformational change that prevents DNA binding, thereby lifting the repression and causing zinc uptake genes such as ZinT and the ZnuABC zinc transporter to be expressed.[1][2][3]
Quick Facts Identifiers, Organism ...
Zinc uptake regulation protein | |||||||
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Identifiers | |||||||
Organism | Escherichia coli | ||||||
Symbol | Zur | ||||||
PDB | 4MTD | ||||||
UniProt | P0AC51 | ||||||
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