![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/a/aa/BloodDonationRedCross.jpg/640px-BloodDonationRedCross.jpg&w=640&q=50)
Whole blood
Unseparated donated human blood / From Wikipedia, the free encyclopedia
Whole blood (WB) is human blood from a standard blood donation.[1] It is used in the treatment of massive bleeding, in exchange transfusion, and when people donate blood to themselves.[1][2] One unit of whole blood (~517 mls) brings up hemoglobin levels by about 10 g/L.[3][4] Cross matching is typically done before the blood is given.[2][5] It is given by injection into a vein.[6]
![]() A Red Cross whole blood donation | |
Clinical data | |
---|---|
Routes of administration | IV |
ATC code | |
Identifiers | |
ChemSpider |
|
Side effects include red blood cell breakdown, high blood potassium, infection, volume overload, lung injury, and allergic reactions such as anaphylaxis.[2][3] Whole blood is made up of red blood cells, white blood cells, platelets, and blood plasma.[3] It is best within a day of collection; however, can be used for up to three weeks.[3][5][7] The blood is typically combined with an anticoagulant and preservative during the collection process.[8]
The first transfusion of whole blood was in 1818; however, common use did not begin until the First and Second World Wars.[5][9] It is on the World Health Organization's List of Essential Medicines.[10][11] In the 1980s the cost of whole blood was about US$50 per unit in the United States.[12] Whole blood is not commonly used outside of the developing world and military.[2] It is used to make a number of blood products including packed red blood cells, platelet concentrate, cryoprecipitate, and fresh frozen plasma.[1]