User:Mr. Ibrahem/Cimetidine
From Wikipedia, the free encyclopedia
Cimetidine, sold under the brand name Tagamet among others, is a medication used to treat stomach ulcers, gastroesophageal reflux disease (GERD), heart burn, and upper GI bleeding.[8][9] It may also be used for allergic reactions.[9] It is taken by mouth or by injection.[9] Onset is within an hour with effects lasting for up to 5 hours.[10]
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Pronunciation | /sɪˈmɛtɪdiːn/ or /saɪˈmɛtɪdiːn/ |
Trade names | Tagamet, others[1] |
Other names | SKF-92334[2] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682256 |
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Routes of administration | By mouth, intramuscular injection, intravenous infusion[3] |
Drug class | H2 receptor antagonist[1] |
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Bioavailability | 60–70%[4][5] |
Protein binding | 13–25%[5][6] |
Metabolism | Liver[5] |
Metabolites | • Cimetidine sulfoxide[5] • Hydroxycimetidine[5] • Guanyl urea cimetidine[5] |
Onset of action | 30 minutes[7] |
Elimination half-life | 123 minutes (~2 hours)[6] |
Duration of action | 4–8 hours[3] |
Excretion | Urine[6] |
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Formula | C10H16N6S |
Molar mass | 252.34 g·mol−1 |
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Common side effects include dizziness, headache, sleepiness, and diarrhea.[9] Prolonged use may result in breast enlargement.[9] Other side effects may include arrythmias, pneumonia, and confusion.[9] There is no evidence of harm in pregnancy, but such use has not been well studied.[11] H2 receptor antagonist that inhibits stomach acid production.[1]
Cimetidine was developed in 1971 and came into commercial use in 1977.[12][13] It is available as a generic medication.[8] In the United Kingdom a month of medication costs the NHS about £16 as of 2021.[8] This amount in the United States is about 33 USD.[14]