Translationally controlled tumor protein (TCTP) is a protein that in humans is encoded by the TPT1 gene.[4][5][6] TPT1 is mapped to 13q12-q14 on chromosome 13.[5] The human gene contains five introns and six exons, TPT1 contains a promoter with a canonical TATA-box and several promoter elements, which are well-conserved in mammals.[7] The assay with reporter gene exhibits a strong promoter activity comparable to viral promoters.[8]
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TCTP protein is also known as p23,[9] Fortilin,[10] and histamine-releasing factor.[11][12]
TCTP is a multifunctional and highly conserved protein that existed ubiquitously in different eukaryote species and distributed widely in various tissues and cell types.[13]
TCTP in the human is a growth-related, calcium-binding protein.[14]