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Thyroid peroxidase
Enzyme expressed mainly in the thyroid gland / From Wikipedia, the free encyclopedia
Thyroid peroxidase, also called thyroperoxidase (TPO), thyroid specific peroxidase or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones.[1] In humans, thyroperoxidase is encoded by the TPO gene.[2]
Quick Facts iodide peroxidase, Identifiers ...
iodide peroxidase | |||||||||
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![]() iodide peroxidase monomer, Zobellia galactanivorans | |||||||||
Identifiers | |||||||||
EC no. | 1.11.1.8 | ||||||||
CAS no. | 9031-28-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
thyroid peroxidase | |||||||
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Identifiers | |||||||
Symbol | TPO | ||||||
NCBI gene | 7173 | ||||||
HGNC | 12015 | ||||||
OMIM | 606765 | ||||||
RefSeq | NM_175722 | ||||||
UniProt | P07202 | ||||||
Other data | |||||||
EC number | 1.11.1.8 | ||||||
Locus | Chr. 2 pter-p24 | ||||||
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