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Taxane
Chemical compound / From Wikipedia, the free encyclopedia
Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents.[2][3] Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
Quick Facts Names, Identifiers ...
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Names | |
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IUPAC name
Taxane[1] | |
Systematic IUPAC name
(4R,4aR,6S,9R,10S,12aS)-4,9,12a,13,13-Pentamethyltetradecahydro-6,10-methanobenzo[10]annulene | |
Identifiers | |
3D model (JSmol) |
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ChemSpider | |
PubChem CID |
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Properties | |
C20H36 | |
Molar mass | 276.508 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Taxanes present difficulties in formulation as medicines because they are poorly soluble in water.