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TNNT2
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene.[5][6] Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.
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The TNNT2 gene is located at 1q32 in the human chromosomal genome, encoding the cardiac muscle isoform of troponin T (cTnT). Human cTnT is an ~36-kDa protein consisting of 297 amino acids including the first methionine with an isoelectric point (pI) of 4.88. It is the tropomyosin- binding and thin filament anchoring subunit of the troponin complex in cardiac muscle cells.[7][8][9] TNNT2 gene is expressed in vertebrate cardiac muscles and embryonic skeletal muscles.[8][9][10]