Sodium voltage-gated channel alpha subunit 9 (also Nav1.7) is a sodium ion channel that in humans is encoded by the SCN9A gene.[5][6][7] It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at the dorsal root ganglion (DRG) and trigeminal ganglion; and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.[8][9]
Quick Facts SCN9A, Available structures ...
SCN9A |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/4/42/PDB_1byy_EBI.jpg/250px-PDB_1byy_EBI.jpg) |
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Identifiers |
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Aliases | SCN9A, ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP, sodium voltage-gated channel alpha subunit 9 |
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External IDs | OMIM: 603415; MGI: 107636; HomoloGene: 2237; GeneCards: SCN9A; OMA:SCN9A - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sural nerve
- spinal ganglia
- stromal cell of endometrium
- trigeminal ganglion
- testicle
- Achilles tendon
- epithelium of colon
- right lobe of liver
- right testis
- left testis
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| Top expressed in | - lumbar spinal ganglion
- olfactory epithelium
- trigeminal ganglion
- superior cervical ganglion
- median eminence
- arcuate nucleus
- supraoptic nucleus
- paraventricular nucleus of hypothalamus
- dorsomedial hypothalamic nucleus
- ventromedial nucleus
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| More reference expression data |
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BioGPS | |
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Wikidata |
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