Sodium-calcium exchanger
Antiporter membrane protein that removes calcium from cells / From Wikipedia, the free encyclopedia
The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). A single calcium ion is exported for the import of three sodium ions.[1] The exchanger exists in many different cell types and animal species.[2] The NCX is considered one of the most important cellular mechanisms for removing Ca2+.[2]
Quick Facts solute carrier family 8 (sodium/calcium exchanger), member 1, Identifiers ...
solute carrier family 8 (sodium/calcium exchanger), member 1 | |||||||
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Identifiers | |||||||
Symbol | SLC8A1 | ||||||
Alt. symbols | NCX1 | ||||||
NCBI gene | 6546 | ||||||
HGNC | 11068 | ||||||
OMIM | 182305 | ||||||
RefSeq | NM_021097 | ||||||
UniProt | P32418 | ||||||
Other data | |||||||
Locus | Chr. 2 p23-p21 | ||||||
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Quick Facts solute carrier family 8 (sodium-calcium exchanger), member 2, Identifiers ...
solute carrier family 8 (sodium-calcium exchanger), member 2 | |||||||
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Identifiers | |||||||
Symbol | SLC8A2 | ||||||
NCBI gene | 6543 | ||||||
HGNC | 11069 | ||||||
OMIM | 601901 | ||||||
RefSeq | NM_015063 | ||||||
UniProt | Q9UPR5 | ||||||
Other data | |||||||
Locus | Chr. 19 q13.2 | ||||||
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Quick Facts solute carrier family 8 (sodium-calcium exchanger), member 3, Identifiers ...
solute carrier family 8 (sodium-calcium exchanger), member 3 | |||||||
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Identifiers | |||||||
Symbol | SLC8A3 | ||||||
NCBI gene | 6547 | ||||||
HGNC | 11070 | ||||||
OMIM | 607991 | ||||||
RefSeq | NM_033262 | ||||||
UniProt | P57103 | ||||||
Other data | |||||||
Locus | Chr. 14 q24.1 | ||||||
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"Ncx" redirects here. For NCX, see NCX.
The exchanger is usually found in the plasma membranes and the mitochondria and endoplasmic reticulum of excitable cells.[3][4]