Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[5][6][7] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme.[8][9] It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al. 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID: AIZ72728.1) and insects.[10] It is also called Sgne1 and Secretogranin V. In C. elegans, it was originally called e7B2[11] and then renamed Seven B Two (gene name sbt-1).[12] There is a Pfam entry for this protein: Secretogranin_V (PF05281).
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