Quinidine
Antiarrythmic medication / From Wikipedia, the free encyclopedia
Not to be confused with quinine or quifenadine.
Quinidine is a class IA antiarrhythmic agent used to treat heart rhythm disturbances.[1] It is a diastereomer of antimalarial agent quinine,[2] originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as a prolonged QT interval. As of 2019, its IV formulation is no longer being manufactured for use in the United States.[3]
Quick Facts Clinical data, Trade names ...
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Trade names | Quinaglute, Quinidex |
Other names | (2-Ethenyl-4-azabicyclo[2.2.2]oct-5-yl)-(6-methoxyquinolin-4-yl)-methanol |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth, intramuscular injection, intravenous |
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Bioavailability | 70–85% |
Metabolism | 50–90% (by liver) |
Elimination half-life | 6–8 hours |
Excretion | By the liver (20% as unchanged quinidine via urine) |
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ECHA InfoCard | 100.000.254 |
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Formula | C20H24N2O2 |
Molar mass | 324.424 g·mol−1 |
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