Proton-pump inhibitor
Class of drugs for reducing stomach acid / From Wikipedia, the free encyclopedia
Proton-pump inhibitors (PPIs) are a class of medications that cause a profound and prolonged reduction of stomach acid production. They do so by irreversibly inhibiting the stomach's H+/K+ ATPase proton pump.[1]
Quick Facts Class identifiers, Use ...
Proton-pump inhibitor | |
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Drug class | |
Class identifiers | |
Use | Reduction of gastric acid production |
ATC code | A02BC |
Mechanism of action | Enzyme inhibitor |
Biological target | H+/K+ ATPase |
Clinical data | |
Drugs.com | Drug Classes |
WebMD | MedicineNet |
External links | |
MeSH | D054328 |
Legal status | |
In Wikidata |
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They are the most potent inhibitors of acid secretion available.[2] Proton-pump inhibitors have largely superseded the H2-receptor antagonists, a group of medications with similar effects but a different mode of action, and heavy use of antacids.[3]
PPIs are among the most widely sold medications in the world. The class of proton-pump inhibitor medications is on the World Health Organization's List of Essential Medicines.[4][5] Omeprazole is the specific listed example.[4][5]