Protein Z (PZ or PROZ), vitamin K-dependent protein Z, is a protein encoded in the human by the PROZ gene.[5][6]
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Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is a glycoprotein. Protein Z functions to inhibit blood coagulation by binding to an inhibitor.[7] It is a GLA domain protein and thus Vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.